Chemical interaction of phosphoric acid ester with hydroxyapatite
Chemical interaction of phosphoric acid ester with hydroxyapatite
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DOI：
10.1177/154405910608501014
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发表时间：
2006-10-01
影响因子：
7.6
通讯作者：
Van Meerbeek, B.
中科院分区：
文献类型：
--
作者：
Fukegawa, D.;Hayakawa, S.;Van Meerbeek, B.
在现代牙科粘合剂中使用的功能单体中，发现10-甲基丙烯酰氧癸基磷酸二氢酯（MDP）与羟基磷灰石（HAp）的化学相互作用最强烈、最稳定。这种效应被认为是基于MDP的自酸蚀粘合剂对牙釉质/牙本质的上级粘结效果的基础。为了充分阐明MDP与HAp的化学相互作用和反应性，我们使用P-31 CP-MAS NMR光谱和粉末X射线衍射。在乙醇水溶液中，Ca离子从HAp中浸出，在短期内在HAp表面形成MDP-钙盐（CaMHP 2）层状结构。当允许MDP相互作用较长时间（< 24小时）时，CaHPO 4中心点2 H（2）O沉淀在该MDP-钙盐层状结构的顶部上。因此，MDP与HAp的强烈化学作用是由于MDP吸附导致HAp表面溶解，随后沉积溶解度低于CaHPO 4中心点2 H（2）O的MDP-钙盐。
Among functional monomers used in contemporary dental adhesives, 10-methacryloyloxydecyl dihydrogen phosphate ( MDP) has been found to interact chemically with hydroxyapatite (HAp) most intensively and stably. This effect was thought to be the basis of the superior bonding effectiveness of MDP-based self-etch adhesives to enamel/ dentin. To elucidate fully the chemical interaction and reactivity of MDP with HAp, we used P-31 CP-MAS NMR spectroscopy and powder x-ray diffraction. In an aqueous ethanol solution, Ca ions were leached from HAp to form, at short term, a MDP-calcium salt (CaMHP2) layered structure on the HAp surface. When MDP was allowed to interact for longer time (< 24 hrs), CaHPO4 center dot 2H(2)O precipitated on top of this MDP-calcium salt layered structure. In conclusion, the intense chemical interaction of MDP with HAp must be ascribed to superficial dissolution of HAp induced by the MDP adsorption and subsequent deposition of MDP-calcium salt with a solubility lower than that of CaHPO4 center dot 2H(2)O.