DIFFERENTIAL-EFFECTS OF CLASSICAL AND ATYPICAL ANTI-PSYCHOTIC DRUGS ON A9 AND A10 DOPAMINE NEURONS
DIFFERENTIAL-EFFECTS OF CLASSICAL AND ATYPICAL ANTI-PSYCHOTIC DRUGS ON A9 AND A10 DOPAMINE NEURONS
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DOI：
10.1126/science.6136093
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
WANG, RY
中科院分区：
文献类型：
--
作者：
WHITE, FJ;WANG, RY
经典抗精神病药物的长期治疗减少了大鼠大脑黑质（A9）和腹侧被盖区（A10）自发活动的多巴胺神经元的数量。非典型抗精神病药物治疗选择性地减少A10多巴胺神经元的数量。缺乏抗精神病作用的相关药物未能降低多巴胺活性。非典型抗精神病药物不能降低A9多巴胺神经元的活性可能与它们引起迟发性运动障碍的可能性较低有关，A10神经元的失活可能与治疗过程中治疗效果的延迟有关。
Prolonged treatment with classical antipsychotic drugs decreased the number of spontaneously active dopamine neurons in both the substantia nigra (A9) and the ventral tegmental area (A10) of the rat brain. Treatment with atypical antipsychotic drugs selectively decreased the number of A10 dopamine neurons. Related drugs lacking antipsychotic efficacy failed to decrease dopamine activity. The inability of atypical antipsychotic drugs to decrease A9 dopamine neuronal activity may be related to their lower potential for causing tardive dyskinesia and the inactivation of A10 neurons may be involved in the delayed onset of therapeutic effects during treatment.