Association between triclosan exposure and obesity measures among 7-year-old children in northern China
Association between triclosan exposure and obesity measures among 7-year-old children in northern China
复制标题
中国北方7岁儿童三氯生暴露与肥胖指标的关系
DOI：
10.1016/j.ecoenv.2022.113610
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发表时间：
2022
影响因子：
6.8
通讯作者：
Ying Tian
中科院分区：
文献类型：
--
作者：
Yi Hu;Guodong Ding;Cheng Lv;Qianlong Zhang;Yan Zhang;Tao Yuan;Junjie Ao;Yu Gao;Yankai Xia;Xiaodan Yu;Ying Tian
三氯生（TCS）是一种广泛使用的合成抗菌化合物，人类普遍接触。动物研究表明，TCS暴露有致肥作用，但关于其对儿童肥胖影响的知识有限。目的：探讨中国北方地区TCS暴露与儿童肥胖的关系。本研究纳入423名参加山东省莱州湾出生队列7岁随访的儿童。采用高效液相色谱-串联质谱法测定儿童尿样中TCS的暴露量。测量或计算他们的身高、体重、腰围、体脂率、身体质量指数（BMI）和腰高比（WHtR）。BMI z-score≥85百分位定义为超重/肥胖，WHtR≥0.5定义为腹部肥胖。采用多变量线性回归、广义线性模型（GLMs）和多变量逻辑回归来检验TCS暴露与儿童肥胖测量之间的关系。线性回归显示，TCS浓度作为连续变量处理时，与BMI z-score （β = 0.12, 95% CI: 0.01, 0.24）和体脂率（β = 0.82, 95% CI: 0.13, 1.52）呈正相关。当TCS浓度被分类为四水平有序变量时，GLMs的结果与连续变量相似，且两者的正趋势均显著（BMI z-score p -trend = 0.049，体脂率p -trend = 0.023）。此外，与对照组相比，较高的TCS水平与腹部肥胖的风险增加约2-3倍相关（p -trend = 0.044）。中国北方地区7岁儿童暴露于TCS与肥胖呈正相关。考虑到横断面研究设计，有必要进行大规模的前瞻性研究来证实我们的发现。•儿童普遍接触三氯生（TCS）。•我们评估了7岁儿童TCS暴露与肥胖的关系。•TCS与儿童BMI z-score和体脂率呈正相关。•TCS与腹部肥胖的风险增加有关。
Triclosan (TCS) is a widely used synthetic antibacterial compound with ubiquitous human exposure. Animal studies have suggested the obesogenic effect of TCS exposure, but knowledge regarding its impacts on childhood obesity was limited. To investigate the associations of TCS exposure with childhood obesity in northern China. This study included 423 children who participated in the 7-year-old follow-up visits of Laizhou Wan Birth Cohort in Shandong, northern China. Children’s TCS exposure were determined in spot urine samples via high performance liquid chromatography-tandem mass. Their height, weight, waist circumference, body fat percentage, body mass index (BMI), and waist-to-height ratio (WHtR) were measured or calculated. BMI z-score ≥ 85th percentile was defined as overweight/obesity, and WHtR ≥ 0.5 was considered to be abdominal obesity. Multivariable linear regressions, generalized linear models (GLMs), and multivariable logistic regressions were performed to examine the associations between TCS exposure and obesity measures in children. Linear regressions showed that TCS concentrations, when treated as continuous variables, were positively associated with BMI z-score (β = 0.12, 95% CI: 0.01, 0.24) and body fat percentage (β = 0.82, 95% CI: 0.13, 1.52). When TCS concentrations were categorized as a four-level ordinal variable, the results of GLMs were similar those of continuous variables and both of the positive trends were significant ( p -trend = 0.049 for BMI z-score; p -trend = 0.023 for body fat percentage). Moreover, the higher TCS levels versus reference group were associated with an approximate 2–3 fold increased risk of abdominal obesity ( p -trend = 0.044). Exposure to TCS was positively associated with obesity measures among 7-year-old children in northern, China. Given to the cross-sectional study design, a large prospective study is warranted to confirm our findings. • Exposure to triclosan (TCS) is ubiquitous in children. • We assessed the associations of TCS exposure with obesity in 7-year-old children. • TCS was positively associated with child BMI z-score and body fat percentage. • TCS was associated with an increased risk for abdominal obesity.