Regulation of animal behavior by epigenetic regulators.
Regulation of animal behavior by epigenetic regulators.
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DOI：
10.2741/4769
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发表时间：
2019-03
期刊：
影响因子：
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通讯作者：
Kouhei Shimaji;Saki Tomida;M. Yamaguchi
中科院分区：
文献类型：
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作者：
Kouhei Shimaji;Saki Tomida;M. Yamaguchi
动物中的表观遗传调节诱导对基因表达的快速和持久的影响，以响应经常影响动物行为的环境变化。在过去的十年中，越来越多的研究揭示了表观遗传调控如何影响动物的行为，如学习和记忆，交配和求偶，昼夜睡眠-觉醒周期，以及觅食/饥饿诱导的多动。在这篇综述的每一节中，我们讨论了我们从哺乳动物（主要是小鼠模型）研究中学到的东西。然后，我们强调果蝇模型的研究，以比较与小鼠模型的数据。最后，我们讨论了几个悬而未决的问题和未来的发展在这一领域。
Epigenetic regulation in animals induces rapid and long-lasting effects on gene expression in response to environmental changes that frequently affect animal behavior. In the last decade, accumulating studies have revealed how epigenetic regulation affects the behavior of animals, such as learning and memory, mating and courtship, the circadian sleep-wake cycle, and foraging/starvation-induced hyperactivity. In each section of this review, we discuss what we have learned from studies with mammals, mostly mouse models. We then highlight studies with Drosophila models to compare data with mouse models. Finally, we discuss several unanswered questions and future developments in this field.