The effects of short-term hormone replacement therapy on long-term bone mineral density
The effects of short-term hormone replacement therapy on long-term bone mineral density
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DOI：
10.1080/13697130701370435
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发表时间：
2007-06-01
期刊：
影响因子：
2.8
通讯作者：
Steel, S. A.
中科院分区：
文献类型：
--
作者：
Middleton, E. T.;Steel, S. A.
介绍短期激素替代疗法(HRT)可缓解更年期症状并增加骨密度(BMD)，但停药后骨丢失会再次发生。这项研究评估短期HRT是否提供长期的BMD益处。方法这是一项前瞻性研究，对象为50-54岁的女性，随访9年。结果长期激素替代治疗组髋部骨密度显著增加(2.4%，P<0.001)，脊柱骨密度显著增加(8.0%，P<；0.001)。未经治疗的女性髋部(-4.2%，p<；0.001)和脊柱(-3.5%，p<；0.001)的骨密度下降。短期HRT组的女性在9年内髋部(-1.6%，p=0.08)或脊柱(-1.4%，p=0.18)的骨密度没有显著下降。短期HRT组9年后腰椎骨密度(差值0.023 g/cm(2)，p=0.048)和髋部骨密度(差值0.016 g/cm(2)，p=0.042)均显著高于非HRT组(P=0.042)。绝经后早期的短期激素替代疗法可提供长期的骨密度益处。
Introduction Short-term hormone replacement therapy (HRT) relieves menopausal symptoms and increases bone mineral density (BMD), but bone loss reoccurs upon discontinuation. This study assesses whether short-term HRT provides long-term BMD benefits.Method This was a prospective study of women aged 50-54 years followed up for 9 years. Women were categorized into three groups according to the treatment they received: No-HRT (n = 340), Short-term HRT (2-4 years, n = 60), and Long-term HRT (9 years, n = 18 7).Results BMD increased significantly at the hip (2.4%, p < 0.001) and spine (8.0%, p < 0.001) over 9 years in the Long-term HRT group. Women without treatment lost BMD at the hip (-4.2%, p < 0.001) and spine (-3.5%, p < 0.001). Women in the Short-term HRT group had no significant loss of BMD at the hip (- 1.6%, p = 0.08) or spine (-1.4%, p=0.18) over 9 years. BMD in the Short-term HRT group was significantly higher at 9 years than in the No-HRT group at both spine (difference 0.023 g/cm(2), p = 0.048) and hip (difference 0.016 g/cm(2), p = 0.042).Conclusion After 9 years, women who had taken short-term HRT had no significant loss of BMD and were better off in terms of BMD than those left untreated. Short-term HRT in the early postmenopausal period provides long-term BMD benefits.