Acute pulmonary and moderate cardiovascular responses of spontaneously hypertensive rats after exposure to single-wall carbon nanotubes
Acute pulmonary and moderate cardiovascular responses of spontaneously hypertensive rats after exposure to single-wall carbon nanotubes
复制标题
自发性高血压大鼠暴露于单壁碳纳米管后的急性肺部和中度心血管反应
DOI：
10.3109/17435390.2011.587905
复制
发表时间：
2012-08-01
期刊：
影响因子：
5
通讯作者：
Chen, Chunying
中科院分区：
文献类型：
--
作者：
Ge, Cuicui;Meng, Li;Chen, Chunying
摘要碳纳米管（CNTs）作为一种具有广泛应用前景的新型纳米材料，其经呼吸道暴露后的不良反应近年来受到广泛关注。在这项研究中，单壁碳纳米管（SWCNTs）含有不同的金属含量被灌输到肺自发性高血压大鼠。在滴注后24和72 h评价肺和心血管系统变化。支气管肺泡灌洗液（BALF）中的炎症，氧化应激和细胞损伤的生物标志物显着增加24小时后暴露的单壁碳纳米管。BALF和血浆中内皮素-1和血浆中血管紧张素转换酶水平升高提示肺循环内皮功能障碍和外周血管血栓形成。这些研究结果表明，呼吸道暴露于单壁碳纳米管可以诱导急性肺和心血管反应，并且患有心血管疾病的个体非常容易受到单壁碳纳米管暴露的影响。金属残留物在单壁碳纳米管中的共存会加剧不利影响。
Abstract As a novel kind of nanomaterial with wide potential applications, the adverse effects of carbon nanotubes (CNTs) have recently received significant attention after respiratory exposure. In this study, single-wall carbon nanotubes (SWCNTs) containing different metal contents were intratracheally instilled into lungs of spontaneously hypertensive rats. Pulmonary and cardiovascular system alterations were evaluated at 24 and 72 h post-instillation. Biomarkers of inflammation, oxidative stress and cell damage in the bronchoalveolar lavage fluid (BALF) were increased significantly 24 h post-exposure of SWCNTs. The increased endothelin-1 levels in BALF and plasma and angiotensin I-converting enzyme in plasma suggested endothelial dysfunction in the pulmonary circulation and peripheral vascular thrombosis. These findings suggest that respiratory exposure to SWCNTs can induce acute pulmonary and cardiovascular responses and individuals with existing cardiovascular diseases are very susceptible to SWCNTs exposure. The co-existence of metal residues in SWCNTs can aggravate the adverse effects.