Localization of synaptophysin immunoreactivity in the human liver.
Localization of synaptophysin immunoreactivity in the human liver.
复制标题
人肝脏中突触素免疫反应性的定位。
DOI：
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发表时间：
1994
影响因子：
1.9
通讯作者：
F. Urano
中科院分区：
文献类型：
--
作者：
N. Kanda;Y. Fukuda;M. Imoto;Y. Koyama;I. Nakano;F. Urano
用免疫组织化学方法研究了4例正常肝、6例慢性活动性肝炎、12例肝硬变和8例肝细胞癌患者正常肝和病变肝组织中突触素的分布。在正常肝脏和慢性肝炎组织中，突触素免疫反应阳性细胞位于小叶和汇管区。在肝硬化组中，可见纤维间隔，但未见假小叶。因此，随着肝硬变的发展，实质神经支配似乎停止了，而实质神经的失神经可能会导致肝硬变的各种功能异常。在肝细胞癌中，沿着癌性窦未见突触素免疫反应。肝细胞癌包膜内的免疫反应阳性斑点比肝硬变的纤维间隔内的小得多。因此，神经功能对肝细胞癌微循环的影响可能很小。
The distribution of synaptophysin, specifically located in nerve terminals, was investigated immunohistochemically in normal and diseased human livers in 4 patients with normal liver, 6 with chronic active hepatitis, 12 with cirrhosis, and 8 with hepatocellular carcinoma. In normal liver and chronic hepatitis synaptophysin immunoreactivity was detected in the lobules and portal areas. In cirrhosis it was found in the fibrous septum but in no pseudolobules. Parenchymal innervation would thus appear to cease with the development of cirrhosis, and denervation from the parenchyma may lead to various functional abnormalities in liver cirrhosis. In hepatocellular carcinoma no synaptophysin immunoreactivity was found along carcinomatous sinusoids. Immunoreactive spots were present in the capsules of hepatocellular carcinoma to a much lesser extent than in the fibrous septum of cirrhosis. Neural functions may thus have little effect on the microcirculation of hepatocellular carcinoma.
DOI：
10.1073/pnas.82.12.4137
发表时间：
1985-01-01
影响因子：
11.1
作者：
JAHN, R;SCHIEBLER, W;GREENGARD, P
通讯作者：
GREENGARD, P