IRON DEPLETION - POSSIBLE CAUSE OF TUMOR-CELL CYTO-TOXICITY INDUCED BY ACTIVATED MACROPHAGES
IRON DEPLETION - POSSIBLE CAUSE OF TUMOR-CELL CYTO-TOXICITY INDUCED BY ACTIVATED MACROPHAGES
复制标题
DOI：
10.1016/0006-291x(84)90288-2
复制
发表时间：
1984-01-01
影响因子：
3.1
通讯作者：
VAVRIN, Z
中科院分区：
文献类型：
--
作者：
HIBBS, JB;TAINTOR, RR;VAVRIN, Z
The experiments reported here provide a possible molecular mechanism for the activated [murine] macrophage cytotoxic effect. Tumor cells that develop cytostasis and inhibition of mitochondrial respiration in response to cocultivation with activated macrophages release a significant fraction of their intracellular 59Fe content. Specific release of 59Fe from target cells begins 4-6 h after initiating cocultivation which is the time point that inhibition of DNA synthesis is first detected. Treatment of tumor cells with metabolic inhibitors causing inhibition of respiration, protein synthesis RNA synthesis, and DNA synthesis to a similar or greater extent than that caused by activated macrophages does not induce release of intracellular 59Fe. Mitochondrial respiration and DNA replication, both strongly inhibited in target cells by activated macrophages, are metabolic pathways with enzymatic activity vulnerable to inhibition by depletion of intracellular Fe.
