Inflammation: A possible pathogenic link to atrial fibrillation
Inflammation: A possible pathogenic link to atrial fibrillation
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DOI：
10.1016/j.mehy.2006.05.034
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发表时间：
2006-01-01
影响因子：
4.7
通讯作者：
Yang, Xiang-Jun
中科院分区：
文献类型：
--
作者：
Pan, Min;Zhu, Jian-Hua;Yang, Xiang-Jun
心房颤动（AF）是临床上最常见的持续性心律失常。尽管有广泛的研究，但房颤的病理生理机制仍不清楚。最近的数据表明，炎症过程与AF的发展有关。该假说的证据包括：（1）组织学研究表明AF患者和AF动物模型中存在炎症浸润;（2）AF患者中炎症标志物增加，并与成功的心脏复律相关。此外，炎症标志物不仅与房颤的发生有关，而且还可独立预测未来房颤发生的风险增加;（3）抗炎药物治疗可降低房颤的复发率。尽管研究表明炎症与房颤之间存在相关性，但许多方面仍有待进一步研究。具体而言，炎症是否是AF的引发者或永久性因素;抗炎药物对心房重构的影响及其在AF复发和永久性中的确切作用。炎症可能为AF的药物中断提供潜在靶点，并可能有利地影响心房。重塑导致重要的临床益处。(c)2006爱思唯尔有限公司保留所有权利。
Atrial fibrillation (AF) is the most common sustained dysrhythmia in clinical practice. Despite the extensive studies, the pathophysiotogical mechanisms in AF, however, remain unclear. More recently, the data has been suggested that inflammatory process has been associated with development of AF. The evidence for the hypotheses included that: (1) Histological studies have demonstrated inflammatory infiltrates in AF patients and in animal models of AF; (2) inflammatory markers are increased in AF patients and is associated with successful cardioversion. And also, Inflammatory markers are not only associated with the presence of AF but also independently predicted increased risk for the development of future AF; (3) treatment with anti-inflammatory agents is associated with a decreased recurrence of AF.Although the studies suggest the existence of an association between inflammation and AF, many aspects remain elusive and require further investigation. Specifically, whether inflammation is an initiator or a perpetuator of AF; the effects of anti-inflammatory drugs on atrial remodeling and their exact role in the recurrence and perpetuation of AF. Inflammation may provide a potential target for pharmacological interruption of AF and may favorably affect atrial. remodeling leading to important clinical benefits. (c) 2006 Elsevier Ltd. All rights reserved.