Persistence of the fluoroquinolone antibiotic difloxacin in soil and lacking effects on nitrogen turnover.
Persistence of the fluoroquinolone antibiotic difloxacin in soil and lacking effects on nitrogen turnover.
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DOI：
10.2134/jeq2011.0459
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发表时间：
2012-07
影响因子：
2.4
通讯作者：
Ingrid Rosendahl;J. Siemens;R. Kindler;J. Groeneweg;J. Zimmermann;S. Czerwinski;M. Lamshöft;V. Laabs;B. Wilke;H. Vereecken;W. Amelung
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文献类型：
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作者：
Ingrid Rosendahl;J. Siemens;R. Kindler;J. Groeneweg;J. Zimmermann;S. Czerwinski;M. Lamshöft;V. Laabs;B. Wilke;H. Vereecken;W. Amelung
在人类治疗和畜牧业中使用氟喹诺酮类抗生素造成的环境风险与其在土壤中的持久性和（生物）可及性有关。为了评估这些方面，我们给猪施用二氟沙星，并将污染的粪便施于土壤。然后，我们评估了在实验室试验，围隔试验和田间试验中的植物存在和不存在的情况下，二氟沙星在土壤中的消散和螯合。连续提取产生不同结合强度的抗生素级分。我们还评估了抗生素对土壤中氮周转的影响（潜在的硝化和反硝化作用）。二氟乙烷几乎无法（生物）获取，在所研究的所有条件下都具有很强的持久性（在散装土壤中的消散半衰期> 217天），迅速形成不可提取的残留物。虽然不同的环境条件并不影响持久性，耗散加速植物根系周围的土壤。对氮周转的影响是有限的，由于该化合物的强结合和小（生物）的可及性，尽管其持久性。
The environmental risks caused by the use of fluoroquinolone antibiotics in human therapeutics and animal husbandry are associated with their persistence and (bio)accessibility in soil. To assess these aspects, we administered difloxacin to pigs and applied the contaminated manure to soil. We then evaluated the dissipation and sequestration of difloxacin in soil in the absence and presence of plants within a laboratory trial, a mesocosm trial, and a field trial. A sequential extraction yielded antibiotic fractions of differing binding strength. We also assessed the antibiotic's effects on nitrogen turnover in soil (potential nitrification and denitrification). Difloxacin was hardly (bio)accessible and was very persistent under all conditions studied (dissipation half-life in bulk soil, >217 d), rapidly forming nonextractable residues. Although varying environmental conditions did not affect persistence, dissipation was accelerated in soil surrounding plant roots. Effects on nitrogen turnover were limited due to the compound's strong binding and small (bio)accessibility despite its persistence.