No Effect of Anodal Transcranial Direct Current Stimulation on Gamma-Aminobutyric Acid Levels in Patients with Recurrent Mild Traumatic Brain Injury.
No Effect of Anodal Transcranial Direct Current Stimulation on Gamma-Aminobutyric Acid Levels in Patients with Recurrent Mild Traumatic Brain Injury.
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经颅阳极直流电刺激对复发性轻度创伤性脑损伤患者的γ-氨基丁酸水平无影响。
DOI：
10.1089/neu.2016.4399
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发表时间：
2017-01
影响因子：
4.2
通讯作者：
S. Wilke;J. List;R. Mekle;R. Lindenberg;M. Bukowski;S. Ott;F. Schubert;B. Ittermann;A. Flöel
中科院分区：
文献类型：
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作者：
S. Wilke;J. List;R. Mekle;R. Lindenberg;M. Bukowski;S. Ott;F. Schubert;B. Ittermann;A. Flöel
在复发性轻度创伤性脑损伤（mTBI）后的慢性期患者中，已报告γ-氨基丁酸（GABA）浓度和受体活性的改变，可能介导微妙但持续的认知缺陷和老年痴呆症的发生率增加。我们评估了是否阳极经颅直流电刺激（atDCS）在初级运动皮层减少GABA浓度和GABAB受体活性的复发性mTBI患者。纳入17例复发性mTBI后慢性期患者（平均年龄25岁，2名女性）和22例健康对照受试者（平均年龄26岁，2名女性）。所有参与者在基线时接受全面的认知测试和详细的脑震荡后症状问卷调查。随后，他们参加了四个实验阶段，包括磁共振波谱（MRS）/atDCS/MRS，经颅磁刺激（TMS）/atDCS/TMS，MRS/sham/MRS或TMS/sham/TMS，以确定atDCS和sham刺激后的GABA浓度（来自MRS）和GABAB受体活性（来自TMS）。与健康对照组相比，mTBI患者在语言流畅性任务上的得分显著降低。基线时GABA浓度与mTBI次数相关，但未发现GABA浓度和GABAB受体活性的组间差异。此外，在mTBI患者或健康对照受试者中未观察到atDCS对GABA浓度和受体活性的影响。GABA的浓度可能会增加与mTBI的数量，但atDCS没有调节GABA的浓度和受体活性，如以前报道的。实验设计和分析的细节，以及各自样本的特征，可能会解释这些差异性的发现，并应在未来更大的研究中加以解决。
In patients in the chronic phase after recurrent mild traumatic brain injury (mTBI), alterations in gamma-aminobutyric acid (GABA) concentration and receptor activity have been reported, possibly mediating subtle but persistent cognitive deficits and increased rate of dementia in older age. We evaluated whether anodal transcranial direct current stimulation (atDCS) over the primary motor cortex reduces GABA concentration and GABAB receptor activity in patients with recurrent mTBI. Seventeen patients (mean age 25, two women) in the chronic phase after recurrent mTBI and 22 healthy control subjects (mean age 26, two women) were included. All participants received comprehensive cognitive testing and detailed questionnaires on post-concussive symptoms at baseline. Subsequently, they participated in four experimental sessions, consisting of either magnetic resonance spectroscopy (MRS)/atDCS/MRS, transcranial magnetic stimulation (TMS)/atDCS/TMS, MRS/sham/MRS, or TMS/sham/TMS to determine GABA concentration (from MRS) and GABAB receptor activity (from TMS) after atDCS and after sham stimulation. Patients with mTBI scored significantly lower on verbal fluency tasks compared with healthy control subjects. GABA concentration at baseline was associated with the number of mTBI, although no group differences in GABA concentration and GABAB receptor activity were found. Moreover, no effects of atDCS on GABA concentration and receptor activity were seen in patients with mTBI or healthy control subjects. GABA concentration may increase with the number of mTBI, but atDCS did not modulate GABA concentration and receptor activity, as has been reported previously. Specifics of experimental design and analysis, but also characteristics of the respective samples, may account for these differential findings, and should be addressed in future larger studies.