Dietary glycemic index and risk of type 2 diabetes mellitus in middle-aged Japanese men
Dietary glycemic index and risk of type 2 diabetes mellitus in middle-aged Japanese men
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DOI：
10.1016/j.metabol.2011.05.015
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发表时间：
2012-01-01
影响因子：
9.8
通讯作者：
Nakagawa, Hideaki
中科院分区：
文献类型：
--
作者：
Sakurai, Masaru;Nakamura, Koshi;Nakagawa, Hideaki
这项队列研究调查了日本中年男性膳食血糖指数 (GI)、血糖负荷 (GL) 与 2 型糖尿病发病率之间的关联，以及胰岛素抵抗和胰腺 B 细胞功能对这种关联的影响。参与者是日本一家金属制品工厂的 1995 名男性员工。使用自我管理的饮食史调查问卷评估饮食 GI 和 GL。糖尿病发病率是在六年期间的年度体检中发现的。使用 Cox 比例风险模型评估 GI、GL 和糖尿病发病率之间的关联。研究期间，133 名参与者患上了糖尿病。 GI 五分位的年龄和体重指数调整后的风险比分别为 1.00（参考）、1.62、1.50、1.68 和 1.80； GL分别为1.00（参考）、1.07、1.48、0.95、0.98。 GI 最高五分位数的风险比显着大于 GI 最低五分位数的风险比。 GI 的影响在胰岛素抵抗最低的亚组中更为明显。胃肠道和胰腺 B 细胞功能与 2 型糖尿病的发病率独立相关； B细胞功能低下且胃肠道最高三分位数的参与者患糖尿病的风险最高。膳食GI与日本中年男性糖尿病的发病率有关。胃肠道和 B 细胞功能与糖尿病的发病率独立相关。 (C) 2012 Elsevier Inc. 保留所有权利。
This cohort study investigated the association between dietary glycemic index (GI), glycemic load (GL), and the incidence of type 2 diabetes mellitus in middle-aged Japanese men, and the effect of insulin resistance and pancreatic B-cell function on the association. Participants were 1995 male employees of a metal products factory in Japan. Dietary GI and GL were assessed using a self-administered diet history questionnaire. The incidence of diabetes was detected in annual medical examinations over a 6-year period. The association between GI, GL, and the incidence of diabetes was evaluated using Cox proportional hazards models. During the study, 133 participants developed diabetes. Age- and body mass index-adjusted hazard ratios across the GI quintiles were 1.00 (reference), 1.62, 1.50, 1.68, and 1.80; and those of GL were 1.00 (reference), 1.07, 1.48, 0.95, and 0.98. The hazard ratio for the highest GI quintile was significantly greater than that for the lowest quintile. The influence of GI was more pronounced in the lowest insulin resistance subgroups. GI and pancreatic B-cell function were independently associated with the incidence of type 2 diabetes mellitus; participants with low B-cell function and the highest tertile of GI had the highest risk of diabetes. Dietary GI is associated with the incidence of diabetes in middle-aged Japanese men. GI and B-cell function were independently associated with incidence of diabetes. (C) 2012 Elsevier Inc. All rights reserved.