During liver regeneration following right portal embolization the growth rate of liver metastases is more rapid than that of the liver parenchyma
During liver regeneration following right portal embolization the growth rate of liver metastases is more rapid than that of the liver parenchyma
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DOI：
10.1046/j.1365-2168.1999.01154.x
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发表时间：
1999-06-01
影响因子：
9.6
通讯作者：
Lasser, P
中科院分区：
文献类型：
--
作者：
Elias, D;de Baere, T;Lasser, P
背景：人类肝转移的相对生长速度尚不清楚。本研究的目的是确定人类肝脏再生过程中肝实质的生长速度和肝脏转移瘤的生长速度。方法：556例肝癌恶性病变患者中，48例术前行选择性右门静脉栓塞诱导左叶肥厚，5例因再生左叶内存在肝转移而选择，采用栓塞前、栓塞后三维CT或CT动脉门静脉造影测量肝转移灶及左叶体积。两次测量的中位数间隔为34天（范围28-40天）。结果：肝实质功能完整者肝转移灶体积增大，肝实质功能受损者肝转移灶体积增大。正常肝的体积增加为59% ~ 127%，而肝转移的体积增加为60% ~ 970%，肝左叶生长罕见与肝转移的比例为1.0 ~ 15.6，单个患者左叶两种转移的生长速度不同。结论：在功能完整的肝实质中，在肝再生或肥厚过程中，转移瘤的生长速度快于肝实质的生长速度，但患者之间和转移瘤之间的生长速度差异较大。
Background: The relative growth rates of human liver metastases are not known. The aim of this study was to determine in humans the growth rate of liver parenchyma during regeneration and the growth rate of liver metastases during the same process.Methods: Among 556 patients hepatectomized for a malignant lesion, 48 underwent preoperative selective right portal vein embolization to induce hypertrophy of the left lobe, Five cases were selected because a liver metastasis was present inside the regenerating left lobe, The volumes of the liver metastasis and left lobe were measured with a three-dimensional technique on pre-embolization and post-embolization computed tomography(CT) or CT arterial portography. The median interval between the two measurements was 34 (range 28-40) days.Results: An increase occurred in the volume of the liver metastasis and the left lobe in the four patients with functionally intact liver parenchyma, bur not in the patient with an impaired parenchyma. The volumetric increase of the normal liver varied from 59 to 127 per cent, compared with 60 to 970 per cent for the liver metastases, The ratio between the growth rare of the left lobe and the liver metastasis varied from 1.0 to 15.6, The growth rates of two metastases in the left lobe of a single patient were different.Conclusion: In functionally intact Liver parenchyma, during hepatic regeneration or hypertrophy, the growth rate of metastases is more rapid that that of the Liver parenchyma, However, a wide variation in growth rate is observed between patients and between metastases.