Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina.
Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina.
复制标题
DOI：
--
复制
发表时间：
1997-01
期刊：
影响因子：
4.6
通讯作者：
A. Jensen;Valerie A. Wallace
中科院分区：
文献类型：
--
作者：
A. Jensen;Valerie A. Wallace
我们发现 Sonic Hedgehog 和 patched 在发育中的小鼠视网膜的相邻区域中表达。用 Sonic Hedgehog 蛋白的氨基末端片段处理围产期小鼠视网膜细胞培养物，会导致细胞总数、视杆细胞、无长突细胞和 Muller 神经胶质细胞中含有溴脱氧尿苷的细胞比例增加，这表明 Sonic Hedgehog 促进视网膜前体细胞的增殖。这些发现表明，hedgehog 和 patched 是哺乳动物和昆虫视网膜发育中保守信号通路的一部分。
We show that Sonic hedgehog and patched are expressed in adjacent domains in the developing mouse retina. Treatment of cultures of perinatal mouse retinal cells with the amino-terminal fragment of Sonic hedgehog protein results in an increase in the proportion of cells that incorporate bromodeoxuridine, in total cell numbers, and in rod photoreceptors, amacrine cells and Muller glial cells, suggesting that Sonic hedgehog promotes the proliferation of retinal precursor cells. These findings suggest that hedgehog and patched are part of a conserved signalling pathway in retinal development in mammals and insects.