Types of Errors on a Semantic Interference Task in Mild Cognitive Impairment and Dementia
Types of Errors on a Semantic Interference Task in Mild Cognitive Impairment and Dementia
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DOI：
10.1037/neu0000542
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发表时间：
2019-07-01
期刊：
影响因子：
2.4
通讯作者：
Duara, Ranjan
中科院分区：
文献类型：
--
作者：
Torres, Valeria L.;Rosselli, Monica;Duara, Ranjan
目的：本研究旨在确定对言语认知任务中不同类型的侵入性错误的定性分析是否有助于检测进展为痴呆前的临床前阶段的细微认知损害。方法：采用Loewenstein-Acevedo语义干扰与学习量表(LASSI-L)对160例认知正常(CN)、遗忘性轻度认知障碍(AMCI)和痴呆患者进行了不同类型的语义干扰比较。样本包括西班牙裔和非西班牙裔欧洲裔美国人。结果：在诊断组中，最常见的入侵错误类型是在引发前瞻语义干扰(PSI)和追溯语义干扰(RSI)的条件下从竞争单词列表中呈现的实际目标，其次是代表三个重叠语义类别之一的入侵，但不是列表A或B中的目标。这些相互竞争的列表入侵(CLI)和语义相关入侵(SRI)区分于aMCI参与者和CN参与者。此外，这些侵入错误与脑淀粉样蛋白负荷有关，表明它们作为AD相关神经变性的潜在主要标志的重要性。种族影响在所有类型的入侵错误中都看不到。结论：两种类型的入侵错误(CLI和SRI)在CN组和aMCI组之间存在差异，且aMCI组的这些入侵错误的发生率高于CN组。这些结果支持了先前关于Lassi-L在异常衰老的最早阶段的敏感性的文献。
Objective: This research aimed to determine whether qualitative analysis of different types of intrusion errors on a verbal cognitive task was useful in detecting subtle cognitive impairment in preclinical stages prior to the progression to dementia. Method: Different types of semantic intrusions on the Loewenstein-Acevedo Scales of Semantic Interference and Learning (LASSI-L) were compared across 160 individuals diagnosed as cognitively normal (CN), amnestic Mild Cognitive Impairment (aMCI), and dementia. The sample included Hispanics and non-Hispanic European Americans. Results: Across diagnostic groups, the most common type of intrusion error was actual targets presented from a competing word list under conditions eliciting proactive semantic interference (PSI), and retroactive semantic interference (RSI), followed by intrusions that represented one of three overlapping semantic categories but none of the targets from List A or B. Nonsemantic intrusions rarely occurred. These competing list intrusions (CLI) and semantically related intrusions (SRI) differentiated between aMCI and CN participants. Further, these intrusion error were related to brain amyloid load, indicating their importance as potential primary markers of AD-related neurodegeneration. Ethnicity effects were not seen across the types of intrusion errors. Conclusions: Two types of intrusion errors (CLI and SRI) showed differences between the CN and aMCI group, with the aMCI group evidencing a higher rate of these intrusion errors compared with the CN group. These results support previous literature about the LASSI-L's sensitivity at the earliest stages of abnormal aging.