Suppression of anterior pituitary in rats bearing a transplantable growth hormone and prolactin-secreting tumor (MtT-W10).
Suppression of anterior pituitary in rats bearing a transplantable growth hormone and prolactin-secreting tumor (MtT-W10).
复制标题
抑制携带可移植生长激素和催乳素分泌肿瘤（MtT-W10）的大鼠的垂体前叶。
作者：
I. Nakayama;P. Nickerson
携带分泌大量生长激素和催乳素的可移植肿瘤的动物的垂体前叶中的生长激素细胞和乳房营养细胞发生退化。肿瘤植入后5周，垂体重量显着减轻。垂体细胞的定量研究至关重要，因为分泌颗粒的尺寸（识别细胞类型最有用的标准之一）变得更小。 4 周时可观察到生长激素细胞的退化变化，由较小的细胞和较少的分泌颗粒组成。第 5 周时，颗粒大小从对照组的 345 ± 5 mμ 减少到荷瘤动物的 257 ± 5 mμ。在乳房营养细胞中，没有观察到细胞大小或每个细胞颗粒数量的变化。第 5 周时，颗粒大小从对照组的 550 ± 14 mμ 降至荷瘤动物的 420 ± 12 mμ。乳房营养细胞中的未成熟颗粒在三周时首次显着减少。溶酶体机制似乎并不是主导......
Involution occurred in somatotrophs and mammotrophs in the anterior pituitary of animals bearing a transplantable tumor secreting large amounts of growth hormone and prolactin. The weight of the pituitary was reduced significantly 5 weeks after tumor implantation. A quantitative study of pituitary cells was essential inasmuch as size of secretory granules, one of the most useful criteria for identification of cell types, became smaller. Involutionary changes in somatotrophs were observable at 4 weeks and consisted of smaller cells and fewer secretory granules. The size of granules decreased from 345 ± 5 mμ for controls to 257 ± 5 mμ for tumor—bearing animals at 5 weeks. In mammotrophs, no change in either the size of the cell or number of granules per cell was observed. The size of granules decreased from 550 ± 14 mμ for controls to 420 ± 12 mμ in tumor—bearing animals at 5 weeks. Immature granules in mammotrophs first decreased significantly at 3 weeks. A lysosomal mechanism does not seem to be the domin...