Expression of Vascular Permeability Factor! Vascular Endothelial Growth Factor by Human Granulosa and Theca Lutein Cells Role in Corpus Luteum Development
Expression of Vascular Permeability Factor! Vascular Endothelial Growth Factor by Human Granulosa and Theca Lutein Cells Role in Corpus Luteum Development
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发表时间：
2007
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通讯作者：
B. Kamat;L. Brown;E. Manseau;D. Senger;H. Dvorak
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作者：
B. Kamat;L. Brown;E. Manseau;D. Senger;H. Dvorak
血管渗透因子/血管内皮生长因子(VPF/VEGF)是一种细胞因子，在许多肿瘤、愈合创面和类风湿关节炎中过表达。VPF/VEGF被认为通过两种方式诱导血管生成和伴随结缔组织间质：1)通过增加微血管通透性，从而改变细胞外基质；2)作为内皮细胞有丝分裂原。VPF/VEGF在动物黄体中已有报道，我们探讨了它可能存在于人卵巢中并在黄体形成中起作用的可能性。我们在此报告了VPF/VEGFmRNA和蛋白在卵泡发育后期的人卵巢颗粒和卵泡膜CEU中的表达，在排卵后的颗粒和卵黄素CEU中表达。因此，在排卵前不久，VPF/VEGFs被用来刺激膜血管通透性的增加。血管内皮细胞生长因子/血管内皮生长因子可能也有助于伴随白念珠菌形成的血管生成和结缔组织间质的生成。VPF/The
Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) is a cytokine that is overexpressed in many tumors, in healing wounds, and in rheumatoid arthritis. VPF/VEGF is thought to induce angiogenesis and accompa-nying connective tissue stroma in two ways: 1), by increasing microvascular permeability, thereby modifying the extracellular matrix and 2), as an endothelial cell mitogen. VPF/VEGF has been reported in animal corpora lutea and we investi-gated the possibility that it might be present in human ovaries and have a role in corpus luteum formation. We here report that VPF/VEGF mRNA and protein are expressed by human ovarian granulosa and theca ceUs late in foUicle development and, subsequent to ovulation, by granulosa and theca lutein ceUs. Therefore, VPF/VEGFis ide-ally positioned to provoke the increased permeability of thecal blood vessels that occurs shortly before ovulation. VPF/VEGF likely also contributes to the angiogenesis and connective tissue stroma generation that accompany corpus albicans formation. VPF/ the