Significance of Imbalance in the Ratio of Serum n-3 to n-6 Polyunsaturated Fatty Acids in Patients With Acute Coronary Syndrome
Significance of Imbalance in the Ratio of Serum n-3 to n-6 Polyunsaturated Fatty Acids in Patients With Acute Coronary Syndrome
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DOI：
10.1016/j.amjcard.2013.10.011
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发表时间：
2014-02-01
影响因子：
2.8
通讯作者：
Daida, Hiroyuki
中科院分区：
文献类型：
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作者：
Nishizaki, Yuji;Shimada, Kazunori;Daida, Hiroyuki
本研究旨在评估急性冠状动脉综合征（ACS）患者血清n-3至n-6多不饱和脂肪酸（PUFA）的平衡。我们招募了1，119名接受治疗的患者，并在日本大都市地区的5个心脏病学部门评估了血清PUFA水平。比较ACS患者和非ACS患者的血清PUFA水平，包括二十碳五烯酸（EPA）、二十二碳六烯酸（DHA）和花生四烯酸（AA）。我们还评估了血清n-3至n-6 PUFAs的平衡，包括EPA/AA和DHA/AA比率。ACS组和非ACS组的EPA/AA值分别为0.46 +/- 0.32和0.50 +/- 0.32。ACS组和非ACS组的DHA/AA值分别为0.95 +/- 0.37和0.96 +/- 0.41。接下来，我们根据EPA/AA的三分位数或DHA/AA的三分位数将患者分为3组，以确定ACS的独立危险因素。根据多因素Logistic回归分析，EPA/AA最低组（
This study aimed to assess the balance of serum n-3 to n-6 polyunsaturated fatty acids (PUFAs) in patients with acute coronary syndrome (ACS). We enrolled 1,119 patients who were treated and in whom serum PUFA level was evaluated in 5 divisions of cardiology in a metropolitan area in Japan. Serum levels of PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid (AA), were compared between patients with and without ACS. We also evaluated the balance of serum n-3 to n-6 PUFAs, including EPA/AA and DHA/AA ratios. EPA/AA values were 0.46 +/- 0.32 and 0.50 +/- 0.32 in the ACS and non-ACS groups, respectively. DHA/AA values were 0.95 +/- 0.37 and 0.96 +/- 0.41 in the ACS and non-ACS groups, respectively. Next, we divided the patients into 3 groups based on the tertiles of EPA/AA or tertiles of DHA/AA to determine the independent risk factors for ACS. According to multivariate logistic regression analysis, the group with the lowest EPA/AA (