Cutaneous manifestations of Campylobacter jejuni infection: A case report and review of the literature.
Cutaneous manifestations of Campylobacter jejuni infection: A case report and review of the literature.
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DOI：
10.1097/ipc.0000000000000827
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发表时间：
2020-03-01
期刊：
影响因子：
--
通讯作者：
Flaherty JP
中科院分区：
文献类型：
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作者：
Roberts SC;Stone SM;Sutton SH;Flaherty JP
一例51岁男性活动性滤泡性淋巴瘤患者在出现自限性腹泻疾病两周后，四肢出现数天的皮肤红斑结节。所有血清免疫球蛋白水平均较低。血液培养培养出空肠弯曲杆菌。患者给予阿奇霉素一周，皮肤结节完全消失。本文对活动性空肠弯曲杆菌感染皮肤表现的文献进行综述。大多数病例发生在免疫功能低下的宿主中，许多人血清免疫球蛋白水平低或无。假设的机制包括肠黏膜缺乏分泌IgA，易使易感患者易位肠道病原体，但皮肤表现的确切发病机制尚不清楚。
A 51 year old man with active follicular lymphoma presented with several days of erythematous skin nodules on all extremities two weeks after a self-limited diarrheal illness. All serum immunoglobulin levels were found to be low. Blood cultures grew Campylobacter jejuni. The patient was given one week of azithromycin with complete resolution of his skin nodules. The literature of skin manifestations seen in active Campylobacter jejuni infection are reviewed. The majority of cases occur in immunocompromised hosts, many with low or no serum immunoglobulin levels. Postulated mechanisms include a lack of secretory IgA in intestinal mucosa predisposing susceptible patients to translocated enteric pathogens however the precise pathogenesis underlying cutaneous manifestations are unknown.