FAMILY HISTORY AND RISK OF PRIMARY OPEN-ANGLE GLAUCOMA - THE BALTIMORE EYE SURVEY
FAMILY HISTORY AND RISK OF PRIMARY OPEN-ANGLE GLAUCOMA - THE BALTIMORE EYE SURVEY
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DOI：
10.1001/archopht.1994.01090130079022
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发表时间：
1994-01-01
影响因子：
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通讯作者：
JAVITT, JC
中科院分区：
文献类型：
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作者：
TIELSCH, JM;KATZ, J;JAVITT, JC
目的：原发性开角型青光眼与青光眼家族史有关。我们使用的数据从巴尔的摩眼睛调查，以研究这种association.Design：一项基于人口的患病率调查确定了161例原发性开角型青光眼5308黑人和白色居民中东巴尔的摩，I\iId，谁是40岁或以上。通过访谈确定家族史，包括所有一级亲属（父母、兄弟姐妹和子女）。结果：原发性开角型青光眼与青光眼病史的经χ 2校正的相关性在兄弟姐妹中（OR = 3.69）高于父母（OR = 2.17）或子女（OR = 1.12）。黑人的比值比略高于白人，并且有选择偏倚的证据，那些事先知道青光眼诊断的人的OR比那些首先通过研究检查得到诊断的人高2 - 3倍（有兄弟姐妹病史者OR = 4.72，无兄弟姐妹病史者OR = 2.77）。家族史是原发性开角型青光眼的一个重要危险因素，尽管临床研究可能夸大了其影响。
Objective: Primary open angle glaucoma has been previously associated with a positive family history of glaucoma. We used data from the Baltimore Eye Survey to examine this association.Design: A population-based prevalence survey identified 161 cases of primary open angle glaucoma among 5308 black and white residents of east Baltimore, i\iId, who were 40 years of age or older. Family history was ascertained by interview and included all first-degree relatives (parents, siblings, and children).Results: Age-adjusted associations of primary open angle glaucoma with a history of glaucoma were higher in siblings (odds ratio [OR] = 3.69) than in parents (OR = 2.17) or children (OR = 1.12). Odds ratios were slightly higher in blacks than in whites, and there was evidence of selection bias, with ORs between two and three times higher for those who had prior knowledge of their glaucoma diagnosis than for those who first received their diagnosis by the study examination (history in siblings OR = 4.72 for those with prior knowledge vs 2.77 for those without).Conclusion: Family history is an important risk factor for primary open angle glaucoma, although clinic-based studies are likely to overstate its impact.