Polymorphisms in the vitamin D receptor gene and type 1 diabetes mellitus risk: An update by meta-analysis
Polymorphisms in the vitamin D receptor gene and type 1 diabetes mellitus risk: An update by meta-analysis
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维生素 D 受体基因多态性与 1 型糖尿病风险：荟萃分析更新
DOI：
10.1016/j.mce.2012.02.003
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发表时间：
2012-05-15
影响因子：
4.1
通讯作者：
Lu, Jianxin
中科院分区：
文献类型：
--
作者：
Zhang, Jie;Li, Wei;Lu, Jianxin
VDR基因中的四个众所周知的多态性(BsmI、FokI、Apai、TaqI)与1型糖尿病(T1 DM)的易感性有关，但到目前为止结果尚不确定。本研究的目的是通过Meta分析探讨VDR基因多态性与T1 DM风险之间的关系。共纳入26项已发表研究中的57项病例对照研究。结果表明，BsmI基因多态与T1 DM发病风险增加相关(Bb+Bbvs.Bb：OR=1.30，95%CI=1.03~1.63)，而FokI、Apai和TaqI基因多态与T1 DM发病风险无关。在按种族进行的亚组分析中，BsmI多态的亚洲亚组仍然存在T1 DM的风险增加；而在其他人群中没有发现其他多态与T1 DM的显著关联。目前的研究结果表明，BsmI基因多态与T1 DM的风险增加有关，特别是在亚洲人。还需要进一步的研究来证实我们的结果。(C)2012爱思唯尔爱尔兰有限公司。保留所有权利。
Four well known polymorphisms (BsmI, FokI, ApaI, TaqI) in the VDR gene have been implicated in susceptibility to type 1 diabetes mellitus (T1DM), but the results to date have been inconclusive. The aim of this study was to investigate the association between polymorphisms in the VDR gene and T1DM risk by meta-analysis. A total of 57 case-control studies in 26 published studies were included. The results indicated that the BsmI polymorphism is associated with increased risk of T1DM (BB + Bb vs. bb: OR = 1.30, 95% CI = 1.03-1.63), while the FokI, ApaI and TaqI polymorphisms were not. In the subgroup analysis by ethnicity, the increased risk of T1DM remained in the Asian subgroup for the BsmI polymorphism; whereas no significant association was found in other populations for other polymorphisms. Results from the current study suggest that the BsmI polymorphism is associated with increased risk of T1DM, especially in Asians. Further studies are needed to confirm our results. (C) 2012 Elsevier Ireland Ltd. All rights reserved.