Impairment of spatial memory consolidation in APP751SL mice results in cue-guided response
Impairment of spatial memory consolidation in APP751SL mice results in cue-guided response
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DOI：
10.1016/j.neurobiolaging.2007.02.010
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发表时间：
2008-07-01
影响因子：
4.2
通讯作者：
Micheau, J.
中科院分区：
文献类型：
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作者：
Blanchard, J.;Martel, G.;Micheau, J.
将5-6月龄和7-8月龄的APP（751 SL）小鼠及其野生型同窝小鼠在水迷宫中进行一次学习，具有三个训练水平（4、12或22次试验）。训练包括找到一个固定位置的水下平台，并用提示标记。在测试过程中，提出了两个平台：一个与空间位置一致，允许位置反应（PR），另一个由线索发出信号，使线索反应（CR）。训练后24小时进行测试时，野生型和5-6个月大的APP（751 SL）小鼠表现出响应策略随训练水平的变化而变化，在训练4次试验时执行CR，在训练12次试验时执行PR，但7-8个月大的APP（751 SL）小鼠仅执行CR。然而，当在12次和22次试验后1小时检测时，它们显示PR，表明巩固缺陷。Zif 268成像显示海马依赖性记忆系统的可塑性损伤，但背外侧尾状核没有。此外，在这些APP（751 SL）小鼠中，选择性影响海马功能的缺陷不能直接与β-淀粉样蛋白沉积的发生相关。(C)2007年爱思唯尔公司All rights reserved.
APP(751SL) mice of 5-6- and 7-8-month-old and their wild-type littermates were submitted to one-session learning in a water-maze with three levels of training (4, 12 or 22 trials). Training consisted in finding a submerged platform with a fixed location and marked by a cue. During testing two platforms were presented: one consistent with the spatial location allowing place-response (PR) and the other signaled by the cue enabling cued-response (CR). When testing occurred 24 h after training, wild-type and 5-6-month-old APP(751SL) mice exhibited a shift in response strategy as a function of training level, by executing CR when trained with 4 trials and PR when trained with 12 trials, but 7-8-monthold APP(751SL) mice executed only CR. However, they displayed PR when tested 1 h after 12- and 22-trial, suggesting a consolidation deficit. Zif268 imaging showed plasticity impairment of the hippocampal-dependent memory system but not of the dorsolateral caudate nucleus. Moreover, in these APP(751SL) mice, the deficit selectively affecting hippocampal function cannot be directly related to the onset of beta-amyloid deposits. (C) 2007 Elsevier Inc. All rights reserved.