Calicheamicin gamma 1I and DNA: molecular recognition process responsible for site-specificity.
Calicheamicin gamma 1I and DNA: molecular recognition process responsible for site-specificity.
复制标题
加利车霉素 gamma 1I 和 DNA：负责位点特异性的分子识别过程。
作者：
N. Zein;M. Poncin;R. Nilakantan;G. Ellestad
Calicheamicin Gamma 1I是最近发现的一种含有双炔的抗肿瘤抗生素，它以双链方式切割DNA，这在药物中是罕见的，具有特定的序列。认为切割的特异性是由于苷元的二炔部分与DNA二级结构的互补性以及硫代苯甲酸酯-碳水化合物尾部与小凹槽的结合而稳定的结果。
Calicheamicin gamma 1I is a recently discovered diyne-ene-containing antitumor antibiotic that cleaves DNA in a double-stranded fashion, a rarity among drugs, at specific sequences. It is proposed that the cutting specificity is due to a combination of the complementarity of the diyne-ene portion of the aglycone with DNA secondary structures and stabilization by association of the thiobenzoate-carbohydrate tail with the minor groove.
影响因子：
16.6
作者：
P. Modrich
通讯作者：
P. Modrich
DOI：
--
发表时间：
1981
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Giloni,L;Takeshita,M;Johnson,F;Iden,C;Grollman,AP
通讯作者：
Grollman,AP