Albumin-mediated extracellular zinc speciation drives cellular zinc uptake.

Albumin-mediated extracellular zinc speciation drives cellular zinc uptake.
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白蛋白介导的胞外锌形态促进细胞锌摄取。

DOI:
10.1039/d2cc02278h
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发表时间:
2022-06-30
影响因子:
4.9
通讯作者:
Blindauer, Claudia A.
Blindauer, Claudia A.
中科院分区:
化学2区
文献类型:
--
作者:
Coverdale, James P. C.;van den Berg, Hugo A.;Khazaipoul, Siavash;Bridgewater, Hannah E.;Stewart, Alan J.;Blindauer, Claudia A.

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细胞外介质在影响细胞摄取金属方面的作用尚未定量描述。在含有白蛋白的化学定义的模型系统中,锌流入内皮细胞与细胞外游离锌浓度相关。游离脂肪酸对锌与白蛋白结合的别构抑制增加了锌通量。脂肪酸改变血浆中锌的形态,增加锌流入内皮细胞。
The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux. Fatty acids alter zinc speciation in plasma, increasing zinc influx into endothelial cells.
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影响因子: --
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