Albumin-mediated extracellular zinc speciation drives cellular zinc uptake.
Albumin-mediated extracellular zinc speciation drives cellular zinc uptake.
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白蛋白介导的胞外锌形态促进细胞锌摄取。
DOI:
10.1039/d2cc02278h
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发表时间:
2022-06-30
影响因子:
4.9
通讯作者:
Blindauer, Claudia A.
中科院分区:
文献类型:
--
作者:
Coverdale, James P. C.;van den Berg, Hugo A.;Khazaipoul, Siavash;Bridgewater, Hannah E.;Stewart, Alan J.;Blindauer, Claudia A.
The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux. Fatty acids alter zinc speciation in plasma, increasing zinc influx into endothelial cells.
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DOI:
10.1016/j.bbalip.2018.09.007
发表时间:
2019-04
期刊:
Biochimica et biophysica acta. Molecular and cell biology of lipids
影响因子:
--
作者:
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作者:
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影响因子:
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作者:
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DOI:
10.1016/j.plefa.2018.07.014
发表时间:
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Prostaglandins, leukotrienes, and essential fatty acids
影响因子:
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作者:
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