Transcription factors and CD4 T cells seeking identity: masters, minions, setters and spikers
Transcription factors and CD4 T cells seeking identity: masters, minions, setters and spikers
复制标题
DOI：
10.1111/imm.12113
复制
发表时间：
2013-07
期刊：
影响因子：
6.4
通讯作者：
G. Vahedi;Y. Kanno;V. Sartorelli;J. O’Shea
中科院分区：
文献类型：
--
作者：
G. Vahedi;Y. Kanno;V. Sartorelli;J. O’Shea
初始 T 细胞响应细胞因子环境的变化而分化并成为不同的亚群。这种专业化是通过顺式调节增强子元件的复杂和动态利用而产生的。在这篇简短的文章中，我们回顾了关于细胞因子环境传感器的相对贡献的最新发现，特别是转录家族转录因子的信号转导器和激活器、“主调节器”以及 T 细胞增强子结构中的其他转录因子。这些发现为信号转导如何影响基因组提供了新的见解。
Naive T cells differentiate and become distinct subsets in response to changes in the cytokine milieu. Such specialization arises through a complex and dynamic utilization of cis‐regulatory enhancer elements. In this brief essay, we review recent findings on the relative contributions of sensors of the cytokine milieu, especially the signal transducer and activator of transcription family transcription factors, ‘master regulators’, and other transcription factors in the enhancer architecture of T cells. These findings provide new insights into how signal transduction impinges upon the genome.