Application of a novel social choice paradigm to assess effects of prenatal endocrine-disrupting chemical exposure in rats (Rattus norvegicus).
Application of a novel social choice paradigm to assess effects of prenatal endocrine-disrupting chemical exposure in rats (Rattus norvegicus).
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应用新型社会选择范式评估产前内分泌干扰化学物质暴露对大鼠（褐家鼠）的影响。
DOI：
10.1037/com0000103
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Gore,AndreaC
中科院分区：
文献类型：
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作者：
Reilly,MichaelP;Weeks,ConnorD;Crews,David;Gore,AndreaC
在怀孕的关键时期，内分泌干扰化学品（EDC）的暴露会引起持久的行为影响，可能是通过干扰大脑的激素组织。这些内分泌干扰物包括多氯联苯（PCBs），这是一类工业化学品。多氯联苯暴露在子宫内导致大鼠交配行为和其他性二态社会互动的改变。以前的许多关于社会行为的研究给了实验动物一个单一或二元选择。这项研究应用了一种更复杂的行为装置，即X形有机玻璃装置（FourPlex），使暴露于多氯联苯或车辆的实验动物能够在4种相同或异性以及不同激素的刺激动物中进行区分和选择状态。我们发现，大鼠能够区分刺激中的四个，并表现出预期的偏好，对异性，对大鼠，特别是在附近进行的行为。产前治疗引起了微妙的变化，行为对刺激大鼠在Fourteen;更强大的影响，被认为是对行为的性二态性。重要的是，这些结果与我们之前的简单二元选择模型的结果不同，表明动物在更复杂的社会范式中的行为并不能预测简单选择模型的结果，反之亦然。
Endocrine-disrupting chemical (EDC) exposures during critical periods of gestation cause long-lasting behavioral effects, presumably by disturbing hormonal organization of the brain. Among such EDCs are polychlorinated biphenyls (PCBs), a class of industrial chemicals. PCB exposure in utero leads to alterations in mating behaviors and other sexually dimorphic social interactions in rats. Many of the previous studies on social behavior gave the experimental animal a single or binary choice. This study applied a more complex behavioral apparatus, an X-shaped Plexiglas apparatus (FourPlex), that enabled an experimental animal exposed to PCBs or a vehicle to distinguish and choose among 4 stimulus animals of the same or opposite sex, and of different hormonal status. We found that rats were able to differentiate among the stimuli in the FourPlex and showed the expected preference for an opposite sex, hormone-treated rat, particularly for behaviors conducted in proximity. Prenatal treatment caused subtle shifts in behavior toward stimulus rats in the FourPlex; more robust effects were seen for the sexual dimorphisms in behavior. Importantly, the results differ from our previous results of a simple binary choice model, showing that how an animal behaves in a more complex social paradigm does not predict the outcome in a simple choice model, and vice versa.