Relationship between serum osteocalcin level and carotid intima-media thickness in a metabolically healthy Chinese population
Relationship between serum osteocalcin level and carotid intima-media thickness in a metabolically healthy Chinese population
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代谢健康中国人群血清骨钙素水平与颈动脉内膜中层厚度的关系
DOI：
10.1186/s12933-015-0245-9
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发表时间：
2015-06-16
影响因子：
9.3
通讯作者：
Jia, Weiping
中科院分区：
文献类型：
--
作者：
Luo, Yuqi;Ma, Xiaojing;Jia, Weiping
背景：骨钙素与动脉粥样硬化之间的关系仍不清楚。这可能是由于与血清骨钙素水平相关的因素（例如代谢相关变量）存在不同程度的混杂。本研究旨在探讨代谢健康人群中血清骨钙素水平与颈动脉内膜中层厚度（C-IMT）之间的关系。方法：上海肥胖研究共招募了476名体重、糖耐量、血压和血脂正常的受试者（年龄范围为20-75岁；155名男性，201名绝经前女性，120名绝经后女性）。横断面研究。有心血管疾病或颈动脉斑块病史的受试者被排除在外。 C-IMT 通过超声检查测量。通过电化学发光免疫测定法评估血清骨钙素水平。结果：整个研究人群的中位 C-IMT 为 0.55 mm，四分位数范围为 0.50-0.60 mm。绝经前女性的C-IMT显着低于男性和绝经后女性（均P < 0.001）。整个人群血清骨钙素水平的中位数（四分位数范围）为 17.02 (13.31-21.47) ng/mL。绝经后女性血清骨钙素水平显着高于男性和绝经前女性（均P < 0.001），男性血清骨钙素水平也显着高于绝经前女性（P < 0.001）。无论是男性还是绝经后女性，C-IMT 与血清骨钙素水平之间均未发现显着相关性。调整年龄后，绝经前女性的 C-IMT 与血清骨钙素水平之间存在显着的负相关，但在调整其他混杂因素后，这种相关性被消除。结论：在代谢健康的中国人群中，血清骨钙素水平与 C-IMT 并不独立相关。
Background: The relationship between osteocalcin and atherosclerosis remains unclear. This might be due to different degrees of confounding from factors that are associated with serum osteocalcin level, such as metabolic-related variables. This study aimed to investigate the relationship between serum osteocalcin level and carotid intima-media thickness (C-IMT) in a metabolically healthy population.Methods: A total of 476 subjects with normal values for weight, glucose tolerance, blood pressure, and lipids (age range, 20-75 years; 155 men, 201 premenopausal women, 120 postmenopausal women) from the Shanghai Obesity Study were recruited for this cross-sectional study. Subjects with a history of cardiovascular disease or carotid plaque were excluded. C-IMT was measured by ultrasonography. Serum osteocalcin level was assessed by an electrochemiluminescence immunoassay.Results: Median C-IMT in the entire study population was 0.55 mm with an interquartile range of 0.50-0.60 mm. C-IMT in premenopausal women was significantly lower than that in men and postmenopausal women (all P < 0.001). The median (interquartile range) of serum osteocalcin level in the entire population was 17.02 (13.31-21.47) ng/mL. Serum osteocalcin level in postmenopausal women was significantly higher than that in men and premenopausal women (all P < 0.001), while the level of serum osteocalcin in men was also significantly higher than that in premenopausal women (P < 0.001). No significant correlation was found between C-IMT and serum osteocalcin level in either men or postmenopausal women. There was a significant, inverse correlations between C-IMT and serum osteocalcin level in premenopausal women after adjustment of age, but this association was eliminated after adjustment for other confounding factors.Conclusions: Serum osteocalcin level was not independently associated with C-IMT in a metabolically healthy Chinese population.