Toxicity of Ultrafine Nickel Particles in Lungs after Intratracheal Instillation
Toxicity of Ultrafine Nickel Particles in Lungs after Intratracheal Instillation
复制标题
超细镍颗粒气管内滴注后对肺的毒性
DOI：
10.1539/joh.40.171
复制
发表时间：
1998
影响因子：
3
通讯作者：
K. Donaldson
中科院分区：
文献类型：
--
作者：
Qunwei Zhang;Y. Kusaka;Kazuhiro Sato;Y. Mo;M. Fukuda;K. Donaldson
气管内滴注后超细镍颗粒对肺部的毒性：张群伟等人。福井医科大学环境卫生系——为了研究超细镍颗粒的肺部急性和亚急性毒性，大鼠气管内分别滴注0、0.1、0.5、1和5毫克超细镍（Uf-Ni）。注射后3天，测定体重和湿肺重量。同时，分析支气管肺泡灌洗液 (BALF) 的乳酸脱氢酶 (LDH)、总蛋白 (TP) 以及总细胞和分类细胞计数。结果显示，随着Uf-Ni剂量从0mg增加到1mg，BALF中的肺损伤和炎症指标明显升高，而1mg和5mg注射Uf-Ni之间的指标没有差异。大鼠气管内滴注 1 mg Uf-Ni，并在 1、3、7、15 和 30 天后分析湿肺重量和支气管肺泡灌洗液 (BALF) 特征。从注射后第 1 天到 30 天，Uf-Ni 对可反映上皮损伤和渗透性的指数（LDH 或 TP）的影响显着增加。肺组织学检查结果普遍证实了BALF数据，显示注射Uf-Ni后1天肺部出现严重炎症，注射后30天仍存在上皮增生和炎症。我们的研究结果表明，小剂量滴注后，Uf-Ni 会引起持续性炎症。
Toxicity of Ultrafine Nickel Particles in Lungs after Intratracheal Instillation: Qunwei Zhang, et al. Department of Environment Health, Fukui Medical University—To study the lung acute and subacute toxicity of ultrafine nickel particles, rats were intratracheally instilled with 0, 0.1, 0.5, 1 and 5 mg ultrafine nickel (Uf‐Ni), respectively. At 3 days after injection, the body weight and wet lung weight were determined. At the same time, bronchoalveolar lavage fluid (BALF) was analyzed for lactate dehydrogenase (LDH), total protein (TP), and total cell and differential cell counts. The results showed that indicators of lung injury and inflammation in BALF were markedly raised with increased Uf‐Ni from 0 to 1 mg, and there were no differences in the indices between injection of Uf‐Ni at 1 mg and at 5 mg. Rats were intratracheally instilled with 1 mg Uf‐Ni, and wet lung weight, and bronchoalveolar lavage fluid (BALF) profiles were analyzed 1, 3, 7, 15 and 30 days later. The effects of Uf‐Ni on indices that can be presumed to reflect epithelial injury and permeability (LDH or TP) were dramatically increased from day 1 up to 30 days after injection. Lung histology findings generally confirmed the BALF data, showing severe lung inflammation at 1 day after injection of Uf‐Ni, and epithelial hyperplasia and inflammation still present at 30 days after injection. Our findings suggest that Uf‐Ni causes persistent inflammation following instillation of a small dose.
影响因子：
10.4
作者：
Huang X;Zhuang Z;Frenkel K;Klein CB;Costa M
通讯作者：
Costa M
影响因子：
10.4
作者：
Oberdörster G;Ferin J;Gelein R;Soderholm SC;Finkelstein J
通讯作者：
Finkelstein J
影响因子：
10.4
作者：
通讯作者：
--