Intervening to enhance cortisol regulation among children at risk for neglect: Results of a randomized clinical trial.
Intervening to enhance cortisol regulation among children at risk for neglect: Results of a randomized clinical trial.
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DOI：
10.1017/s095457941400073x
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发表时间：
2015-08
影响因子：
3.3
通讯作者：
Gordon MK
中科院分区：
文献类型：
--
作者：
Bernard K;Dozier M;Bick J;Gordon MK
下丘脑-垂体-肾上腺(HPA)轴对虐待条件特别敏感。特别是，被忽视的儿童与未被忽视的儿童相比，表现出更平坦的斜率和更低的唤醒值。一种名为依恋和生物行为追赶(ABC)的干预措施被开发出来，以加强对有忽视风险的幼儿的生物和行为调节。干预的有效性是在一项针对参与儿童保护服务的儿童的随机临床试验中评估的。干预后，接受ABC干预的儿童(n=49)比接受对照干预的儿童(n=51)表现出更典型的皮质醇产生，更高的唤醒皮质醇数值和更陡峭的昼夜斜率。这些结果表明，ABC干预在加强生物调节方面是有效的。
The hypothalamus-pituitary-adrenal (HPA) axis is particularly sensitive to conditions of maltreatment. In particular, neglected children have shown a flatter slope with lower wake-up values relative to non-neglected children. An intervention, Attachment and Biobehavioral Catch-up (ABC), was developed to enhance biological and behavioral regulation in young children at risk for neglect. The effectiveness of the intervention was assessed in a randomized clinical trial for children with involvement with Child Protective Services. Following the interventions, children receiving the ABC intervention (n = 49) showed more typical cortisol production, with higher wake-up cortisol values and a steeper diurnal slope than children receiving the control intervention (n = 51). These results suggest that the ABC intervention is effective in enhancing biological regulation.