Potential role of p21 Activated Kinase 1 (PAK1) in the invasion and motility of oral cancer cells.
Potential role of p21 Activated Kinase 1 (PAK1) in the invasion and motility of oral cancer cells.
复制标题
p21活化激酶1（PAK1）在口腔癌细胞的侵袭和运动中的潜在作用。
DOI：
10.1186/s12885-016-2263-8
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发表时间：
2016-05-16
期刊：
影响因子：
3.8
通讯作者：
Pillai MR
中科院分区：
文献类型：
--
作者：
Parvathy M;Sreeja S;Kumar R;Pillai MR
口腔癌是由主要在口腔底部、牙龈、口咽部、下唇和舌底的细胞不受控制的分裂组成的。根据GLOBOCAN 2012报告，口腔癌是印度男性和女性中最常见的癌症之一。尽管在口腔癌的治疗方式方面取得了重大进展，但在过去的几十年里，患者的总体预后并没有改善，因此，这需要新的推动力来确定口腔癌的新治疗靶点。p21活化激酶（PAKs）是参与多种生理功能的潜在治疗靶点。PAKs是丝氨酸-苏氨酸激酶，它们是细胞骨架动力学和细胞运动、通过MAP激酶级联转录、死亡和生存信号传导以及细胞周期进程的重要调节因子。虽然已知PAKs在癌症进展中起着至关重要的作用，但PAKs在口腔癌中的作用和临床意义仍然知之甚少。我们的研究结果表明PAK1在口腔癌细胞系中过表达。用血清生长因子刺激口腔鳞状细胞癌（OSCC）细胞可导致PAK1重新定位，并可能引起深刻的细胞骨架重塑。PAK1还参与了OSCC细胞的侵袭、迁移和细胞骨架重塑。我们的研究表明PAK1可能在OSCC的进展中起着至关重要的作用。研究PAK1及其底物的作用有可能增强我们对口腔癌发生机制的认识以及PAK1在口腔癌中的潜在治疗价值。本文的在线版本（doi:10.1186/s12885-016-2263-8）包含补充材料，可供授权用户使用。
Oral cancer malignancy consists of uncontrolled division of cells primarily in and around the floor of the oral cavity, gingiva, oropharynx, lower lip and base of the tongue. According to GLOBOCAN 2012 report, oral cancer is one of the most common cancers among males and females in India. Even though significant advancements have been made in the field of oral cancer treatment modalities, the overall prognosis for the patients has not improved in the past few decades and hence, this demands a new thrust for the identification of novel therapeutic targets in oral cancer. p21 Activated Kinases (PAKs) are potential therapeutic targets that are involved in numerous physiological functions. PAKs are serine-threonine kinases and they serve as important regulators of cytoskeletal dynamics and cell motility, transcription through MAP kinase cascades, death and survival signalling, and cell-cycle progression. Although PAKs are known to play crucial roles in cancer progression, the role and clinical significance of PAKs in oral cancer remains poorly understood. Our results suggest that PAK1 is over-expressed in oral cancer cell lines. Stimulation of Oral Squamous Cell Carcinoma (OSCC) cells with serum growth factors leads to PAK1 re-localization and might cause a profound cytoskeletal remodelling. PAK1 was also found to be involved in the invasion, migration and cytoskeletal remodelling of OSCC cells. Our study revealed that PAK1 may play a crucial role in the progression of OSCC. Studying the role of PAK1 and its substrates is likely to enhance our understanding of oral carcinogenesis and potential therapeutic value of PAKs in oral cancer. The online version of this article (doi:10.1186/s12885-016-2263-8) contains supplementary material, which is available to authorized users.