Distinguishing the Common Components of Oil- and Water-Based Metalworking Fluids for Assessment of Cancer Incidence Risk in Autoworkers
Distinguishing the Common Components of Oil- and Water-Based Metalworking Fluids for Assessment of Cancer Incidence Risk in Autoworkers
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DOI：
10.1002/ajim.20932
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发表时间：
2011-06-01
影响因子：
3.5
通讯作者：
Eisen, Ellen A.
中科院分区：
文献类型：
--
作者：
Friesen, Melissa C.;Costello, Sadie;Eisen, Ellen A.
背景金属加工液（MWF）-直的、可溶的和合成的-具有重叠的组分。我们推导出基于成分的多环芳烃（PAHs），水基MWF，杀菌剂和亚硝胺的指标来解释这种重叠，并研究它们与癌症发病率的关系。对每种癌症和每种新指标的累积暴露（滞后）进行风险比估计;可溶性MWF对权重k = 0- 1的几个指标的贡献是显著的。结果对于大多数癌症部位，基于成分的指标比单独的MWF类别导致更强的患病-疾病关联。喉癌和膀胱癌与PAH的相关性最强（k = 0）。胃癌和肺癌的保护作用，观察与杀生物剂，一个组件，可能是一个替代endotoxic.Conclusions我们的研究结果提供了支持和澄清可能的病因以前的积极协会，并提供支持区分暴露于油和水基MWF的流行病学研究。Am. J. Ind. Med. 54：450-460，2011. (C)2011 Wiley-Liss，Inc.
Background Metalworking fluids (MWF)-straight, soluble, and synthetic-have overlapping components. We derived constituent-based metrics of polycyclic aromatic hydrocarbons (PAHs), water-based MWF, biocides, and nitrosamines to account for this overlap and examined their relations with cancer incidence.Methods An autoworkers cohort of 30,000 was followed for cancer incidence. Hazard ratios were estimated for each cancer and cumulative exposure (lagged) to each new metric; soluble MWF contributed variably to several metrics with weight k = 0-1.Results For most cancer sites, the constituent-based metrics resulted in stronger exposure-disease associations than the MWF classes alone. Laryngeal and bladder cancer were most strongly associated with PAH (k = 0). Protective effects for stomach and lung cancer were observed with biocide, a component that may be a surrogate for endotoxin.Conclusions Our findings provide support and clarification of possible etiologies for previous positive associations and provide support for distinguishing exposure from oil-and water-based MWF in epidemiologic studies. Am. J. Ind. Med. 54: 450-460, 2011. (C) 2011 Wiley-Liss, Inc.