Differential age-related changes in the regional metencephalic volumes in humans: a 5-year follow-up
Differential age-related changes in the regional metencephalic volumes in humans: a 5-year follow-up
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DOI：
10.1016/s0304-3940(03)00820-6
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发表时间：
2003-10-09
影响因子：
2.5
通讯作者：
Acker, JD
中科院分区：
文献类型：
--
作者：
Raz, N;Rodrigue, KM;Acker, JD
我们检查了两次（间隔5年）接受磁共振成像的健康成年人后脑的变化。小脑半球、前、后蚓部、蚓部小叶结节和脑桥腹侧的体积由不了解受试者特征和扫描时间的操作者测量。在这两项测量中，老年人的小脑半球和小脑蚓部较小，但脑桥腹侧较小。在所有检查的后脑区域均观察到显著的线性收缩。小脑半球的年收缩率最大，小脑蚓部稍小，脑桥最小。既没有性别差异，也没有性别特异性的衰老趋势被发现。我们得出结论，差异年龄相关的收缩的后脑结构发生在健康的成年人，但其幅度不同的横截面估计。(C)2003爱思唯尔爱尔兰有限公司保留所有权利。
We examined changes in the metencephalon of healthy adults who underwent magnetic resonance imaging twice, 5 years apart. The volumes of the cerebellar hemispheres, anterior and posterior vermis, declive-folium-tuber of the vermis, and the ventral pons were measured by operators unaware of subjects' characteristics and the time of scan. The cerebellar hemispheres and the cerebellar vermis, but not the ventral pons, were smaller in older people at both measurements. Significant linear shrinkage was observed in all examined metencephalic regions. Annualized rate of shrinkage was the greatest in the cerebellar hemispheres, somewhat smaller in the vermis, and minimal in the pons. Neither sex differences, nor sex-specific aging trends were found. We conclude that differential age-related shrinkage of the metencephalic structures occurs in healthy adults, but its magnitude differs from cross-sectional estimates. (C) 2003 Elsevier Ireland Ltd. All rights reserved.