Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging
Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging
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DOI：
10.1002/biof.127
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发表时间：
2010-09
期刊：
影响因子：
6
通讯作者：
L. Mouchiroud;L. Molin;Nicolas Dallière;F. Solari
中科院分区：
文献类型：
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作者：
L. Mouchiroud;L. Molin;Nicolas Dallière;F. Solari
世纪之交，全球平均预期寿命为46岁，今天约为65岁。年龄相关疾病发病率的相关增加对公共卫生产生了深远的影响，是我们社会关注的一个重要问题。衰老是一种复杂的、异质的、多因素的现象，是基因与环境多重相互作用的结果。在这篇综述中，我们调查了动物模型，这些模型对于研究衰老机制和识别减缓年龄相关疾病发作的分子都有很大帮助。白藜芦醇（RSV）就是其中之一。我们将报告支持RSV作为一种分子的证据，这种分子通过模拟饮食限制的有益作用发挥作用，并且可能与雷帕霉素和二甲双胍共享共同的下游靶点。虽然这些分子并没有揭示青春之泉的所有秘密，但它们可能有助于我们在老年时保持生活质量。© 2010国际生物化学与分子生物学联合会，Inc.
Life expectancy at the turn of the 20th century was 46 years on average worldwide and it is around 65 years today. The correlative increase in age‐associated diseases incidence has a profound public health impact and is an important matter of concern for our societies. Aging is a complex, heterogeneous, and multifactorial phenomenon, which is the consequence of multiple interactions between genes and environment. In this review, we survey animals models that have been of great help for both investigating mechanism of aging and identifying molecules, which slow down the onset of age‐related diseases. Resveratrol (RSV) is one of those. We will report evidences supporting RSV as a molecule that acts by mimicking the beneficial effects of dietary restriction, and may share common downstream targets with rapamycin and metformin. Although those molecules do not reveal all the secrets of the fountain of youth, they may help us maintaining the quality of life in the old age. © 2010 International Union of Biochemistry and Molecular Biology, Inc.