Vertebrate orthologues of the Drosophila region-specific patterning gene teashirt
Vertebrate orthologues of the Drosophila region-specific patterning gene teashirt
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DOI：
10.1016/s0925-4773(99)00318-4
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发表时间：
2000-03-01
影响因子：
2.6
通讯作者：
Fasano, L
中科院分区：
文献类型：
--
作者：
Caubit, X;Coré, N;Fasano, L
在果蝇中，编码锌指蛋白的teashirt基因在特定的身体部位活跃，形成图案。例如，Teashirt需要在胚胎的躯干（胸部和腹部）tagmata，部分肠道和附件的近端部分。在这里，我们报告的分离脊椎动物的cDNA相关的teashirt。与果蝇一样，人类和小鼠蛋白质具有三个间隔很宽的锌指基序。此外，我们描述了这两个小鼠基因的表达模式。这两种基因在躯干、发育中的四肢和肠道中都表现出区域化的表达模式。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
In Drosophila the teashirt gene, coding for a zinc finger protein, is active in specific body parts for patterning. For example, Teashirt is required in the trunk (thorax and abdomen) tagmata of the embryo, parts of the intestine and the proximal parts of appendages. Here we report the isolation of vertebrate cDNAs related to teashirt. As in Drosophila, human and murine proteins possess three widely spaced zinc finger motifs. Additionally, we describe the expression patterns of the two murine genes. Both genes show regionalised patterns of expression, in the trunk, in the developing limbs and the gut. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.