Removal of osteoclast bone resorption products by transcytosis
Removal of osteoclast bone resorption products by transcytosis
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DOI：
10.1126/science.276.5310.270
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发表时间：
1997-04-11
期刊：
影响因子：
56.9
通讯作者：
Vaananen, HK
中科院分区：
文献类型：
--
作者：
Salo, J;Lehenkari, P;Vaananen, HK
破骨细胞是负责骨吸收的多核细胞。在再吸收周期中，破骨细胞的极性发生了巨大的变化，再吸收细胞显示出四个功能和结构不同的膜结构域。骨降解产物，包括有机和无机的，从皱褶缘膜内吞。然后发现它们在囊泡中通过细胞运输到位于基底膜中间的质膜结构域，在那里它们被释放到细胞外空间。这些结果解释了如何吸收破骨细胞可以同时清除大量的基质降解产物和渗透到骨。
Osteoclasts are multinucleated cells responsible for bone resorption. During the resorption cycle, osteoclasts undergo dramatic changes in their polarity, and resorbing cells reveal four functionally and structurally different membrane domains. Bone degradation products, both organic and inorganic, were endocytosed from the ruffled border membrane. They were then found to be transported in vesicles through the cell to the plasma membrane domain, located in the middle of the basal membrane, where they were liberated into the extracellular space. These results explain how resorbing osteoclasts can simultaneously remove large amounts of matrix degradation products and penetrate into bone.