Highly Efficient Cell-Penetrating Probes of Protein Arginine Deiminases for Functional Proteomics
Highly Efficient Cell-Penetrating Probes of Protein Arginine Deiminases for Functional Proteomics
复制标题
用于功能蛋白质组学的蛋白质精氨酸脱亚胺酶的高效细胞穿透探针
DOI：
10.1002/cbic.201800257
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发表时间：
2018
期刊：
影响因子：
3.2
通讯作者：
Kumar, Sanjai
中科院分区：
文献类型：
--
作者：
Kumar, Sanjai
蛋白质精氨酸脱亚胺酶（PAD）最近出现在几种人类疾病的药物发现计划的最前沿。尽管如此，对它们在人类生物学中的功能作用的精确理解仍有待充分阐明。本报告重点介绍了下一代基于活性的PAD探针的最新发展，这些探针具有高效，细胞活性和代谢稳定性。这一发现将迅速加快PAD生物学在正常和病变细胞中的功能分配，从而在不久的将来开发PAD靶向治疗药物。
Protein arginine deiminases (PADs) have recently emerged at the forefront of drug‐discovery programs for several human disorders. Despite this, a precise understanding of their functional roles in human biology remains to be fully elucidated. This report highlights a recent development of next‐generation activity‐based PAD probes that are highly efficient, cell active, and metabolically stable. This discovery should rapidly expedite functional assignments of PAD biology in both normal and diseased cells, thereby leading to the development of PAD‐targeted therapeutics in the near future.