Valproate reduces spontaneous generalized spikes and waves but not photoparoxysmal reactions in patients with idiopathic generalized epilepsies
Valproate reduces spontaneous generalized spikes and waves but not photoparoxysmal reactions in patients with idiopathic generalized epilepsies
复制标题
丙戊酸钠可减少特发性全身性癫痫患者的自发性全身性棘波和波，但不能减少光阵发性反应
DOI：
10.1111/j.1528-1167.2011.03058.x
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发表时间：
2011
期刊：
影响因子：
5.6
通讯作者：
M. Siniatchkin
中科院分区：
文献类型：
--
作者：
H. Muhle;Esther Ettle;R. Boor;U. Stephani;M. Siniatchkin
目的：特发性广泛性癫痫（IGEs）患者在休息时（自发性SWDs）、过度通气时和对光刺激（光发作反应或PPR）的反应中经常出现间期尖峰波放电（SWDs）。丙戊酸（VPA）是治疗IGE患者的一线抗癫痫药物。在此，我们研究了VPA对患有IGE的儿童和青少年中所有三种类型SWDs的影响。
Purpose: Patients with idiopathic generalized epilepsies (IGEs) often present with interictal spike‐wave discharges (SWDs) at rest (spontaneous SWDs), during hyperventilation, and in response to photic stimulation (photoparoxysmal response or PPR). Valproic acid (VPA) is a first‐line antiepileptic drug for therapy of patients with IGE. Herein we investigated the effect of VPA on all three types of SWDs in children and adolescents with IGE.