Sesquiterpenoid metabolites with antiplasmodial activity from a Caribbean gorgonian coral, Eunicea sp.
Sesquiterpenoid metabolites with antiplasmodial activity from a Caribbean gorgonian coral, Eunicea sp.
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来自加勒比柳珊瑚 (Eunicea sp.) 的具有抗疟原虫活性的倍半萜代谢物。
DOI：
10.1021/np0501684
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Ortega-Barria,Eduardo
中科院分区：
文献类型：
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作者：
Garzon,SandraP;Rodriguez,AbimaelD;Sanchez,JuanA;Ortega-Barria,Eduardo
A chemical investigation of the Caribbean gorgonian octocoralEuniceasp. collected along the northwest coast of Puerto Rico has afforded seven new secondary metabolites,1−7, belonging to several types of sesquiterpenes, including elemane, eudesmane, and germacrane types, along with the known steroidal glycoside8. Some of the new metabolites,4−7, carry an unusual ester side chain at the C-6 position. The structures of all compounds, including their relative stereochemistry, were determined by combined spectroscopic methods. The present compounds exhibited a significant inhibitory effect upon the growth of the malarial parasitePlasmodiumfalciparum.
