Biomimetic bioinks of nanofibrillar polymeric hydrogels for 3D bioprinting
Biomimetic bioinks of nanofibrillar polymeric hydrogels for 3D bioprinting
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DOI：
10.1016/j.nantod.2021.101180
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发表时间：
2021-08
期刊：
影响因子：
17.4
通讯作者：
Yue Wang;Jiahui Li;Yunfeng Li;Bai Yang
中科院分区：
文献类型：
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作者：
Yue Wang;Jiahui Li;Yunfeng Li;Bai Yang
3D生物打印是一种快速新兴的技术，用于制造更接近天然组织生理特征的生物组织结构，从而促进创新研究方向，彻底改变生物材料和生物医学科学的基本理解和实用技术。 3D 生物打印能够精确沉积充满细胞的生物墨水，从而以快速且可扩展的方式制造几何复杂的 3D 仿生组织结构。在过去的十年中，3D生物打印应用的生物墨水工具箱得到了快速发展，然而，生物墨水的开发仍然是该领域的瓶颈之一。仿生纳米纤维水凝胶可以重现细胞外基质的丝状特征和特性，因此可以作为生物墨水通过3D生物打印制造仿生组织结构。在此，我们对基于纳米纤维聚合物水凝胶的仿生生物墨水的当前进展进行了全面的回顾。我们总结了各种结构单元的仿生纳米纤维水凝胶的设计和合成，并讨论了基于纳米纤维聚合物水凝胶的仿生生物墨水的设计标准的基础知识。我们回顾了基于由天然、合成、混合或纳米复合聚合物制成的纳米纤维水凝胶的仿生生物墨水的当前进展。最后，我们总结了仿生生物墨水发展的当前挑战和未来前景，并讨论了仿生生物墨水如何促进生物打印疗法的转化并推动3D生物打印领域的进一步创新。
3D bioprinting is a rapidly emerging technology to manufacture biological tissue constructs that more closely recapitulate physiological features of native tissue, and thus facilitates innovative research directions to revolutionize the fundamental understanding and practical technology in biomaterials and biomedical science. 3D bioprinting enables precise deposition of cell-laden bioinks to fabricate geometrically intricate 3D biomimetic tissue constructs in a fast and scalable fashion. In the past decade, rapid development has been made to expand the bioink toolbox for 3D bioprinting applications, however, bioink development remains one of the bottlenecks in the field. Biomimetic nanofibrillar hydrogels can reproduce the filamentous feature and properties of extracellular matrices, and thus can function as bioinks to fabricate biomimetic tissue constructs by 3D bioprinting. Herein, we provide a comprehensive review on current progress in biomimetic bioinks based on nanofibrillar polymeric hydrogel. We summarize the design and synthesis of biomimetic nanofibrillar hydrogels from various of building blocks, and discuss the fundamentals on design criteria of biomimetic bioinks based on nanofibrillar polymeric hydrogels. We review the current progress of biomimetic bioinks based on nanofibrillar hydrogels that are made from natural, synthetic, hybrid, or nanocomposite polymers. We conclude with the current challenges and future prospects on the development of biomimetic bioinks, and a discussion on how biomimetic bioinks can promote the translation of bioprinted therapies and drive further innovation within the field of 3D bioprinting.