Molecular analysis of deletions in human chromosome 3p2l and the role of resident cancer genes in disease
Molecular analysis of deletions in human chromosome 3p2l and the role of resident cancer genes in disease
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DOI：
10.1093/bfgp/elm007
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发表时间：
2007-01-01
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影响因子：
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通讯作者：
Angeloni, Debora
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作者：
Angeloni, Debora
上皮癌给人类和社会造成沉重负担。据估计[Tyczynski JE，Bray F，Parkin DM. 2000年欧洲肺癌：流行病学、预防和早期发现Lancet Oncol 2003; 4：45-55（综述）]，在欧洲，在2000年，347000人仅死于肺癌，这是最致命的癌症疾病。事实上，3 p21是基因组的一个非常特殊的区域，包含紧密聚集的几种类型的致癌基因（CCG）（Lerman MI，Minna JD.人类染色体3p21.3上630 kb肺癌纯合缺失区：候选肿瘤抑制基因的鉴定和评估。国际肺癌染色体3p21.3肿瘤抑制基因联盟。癌症研究2000; 60：6116-33）。目前的结果显示，与最初认为的不同，许多肿瘤抑制基因（TSG）即使在小的基因组区域中也位于附近。它们可能与不同类型的肿瘤有关，可能具有不同的作用，并可能受到不同人群的遗传背景以及环境污染物的影响这篇综述将讨论基因组缺失的分子分析方法，以揭示3 p21的CCG，将总结目前关于位于该区域的TSGs的知识，并将描述上皮癌发病机理的可能模型。
Epithelial cancers inflict a heavy human and social burden. It was estimated [Tyczynski JE, Bray F, Parkin DM. Lung cancer in Europe in 2000: epidemiology, prevention, and early detection. Lancet Oncol 2003;4:45-55 (Review)] that in Europe, in the year 2000, 347000 persons died of lung cancer alone, the deadliest cancer disease.Loss of heterozygosity and large homozygous deletions of the human chromosome region 3p21 are especially frequent in epithelial cancers of several organs. In fact, 3p21 is a very peculiar region of the genome harbouring, tightly clustered, several types of cancer-causing genes (CCG) (Lerman MI, Minna JD. The 630 kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumour suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. Cancer Res 2000;60:6116-33).Current results show that, unlike it was thought initially, many tumour suppressor genes (TSG) are located close by even in small genomic regions. They may be involved, perhaps with varying role, in different types of tumour, and may be influenced by the genetic background of different human populations as well as by environmental pollutants (cigarette smoking, professional exposure).This review will discuss methods of molecular analysis of genomic deletions to uncover CCG at 3p21, will summarize the present knowledge regarding the TSGs located in this region, and will describe a possible model of epithelial cancer pathogenesis.