SOCE in neurons: Signaling or just refilling?
SOCE in neurons: Signaling or just refilling?
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DOI：
10.1016/j.bbamcr.2015.01.019
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发表时间：
2015-09-01
影响因子：
5.1
通讯作者：
Kuznicki, Jacek
中科院分区：
文献类型：
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作者：
Majewski, Lukasz;Kuznicki, Jacek
在这篇综述中，我们描述了目前的知识，在神经元中的钙池操作的内流（SOCE）和参与这一过程的蛋白质：STIM，以及奥赖和TRP通道。我们解决的问题，是否SOCE仅用于补充钙离子在ER或是否钙离子进入神经元细胞在SOCE也执行信号功能。我们收集的数据表明，SOCE及其组分参与神经元中的重要过程。这对确定治疗脑部疾病的新药物靶点具有重要意义。有证据表明，在神经退行性疾病中，Ca2+稳态和SOCE组分变得失调。因此，不同的目标和策略可能会被确定为这些疾病的潜在治疗。本文是题为：第13届欧洲钙研讨会特刊的一部分。(C)2015作者由爱思唯尔公司出版
In this review we describe the present knowledge about store operated Ca2+ entry (SOCE) in neurons and the proteins involved in this process: STIM, as well as Orai and TRP channels. We address the issue of whether SOCE is used only to refill Ca2+ in the ER or whether Ca2+ that enters the neuronal cell during SOCE also performs signaling functions. We collected the data indicating that SOCE and its components participate in the important processes in neurons. This has implications for identifying new drug targets for the treatment of brain diseases. Evidence indicates that in neurodegenerative diseases Ca2+ homeostasis and SOCE components become dysregulated. Thus, different targets and strategies might be identified for the potential treatment of these diseases. This article is part of a Special Issue entitled: 13th European symposium on calcium. (C) 2015 The Authors. Published by Elsevier B.V.