Dietary patterns and incident cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis
Dietary patterns and incident cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis
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DOI：
10.3945/ajcn.2009.27597
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发表时间：
2009-09-01
影响因子：
7.1
通讯作者：
Jacobs, David R., Jr.
中科院分区：
文献类型：
--
作者：
Nettleton, Jennifer A.;Polak, Joseph F.;Jacobs, David R., Jr.
背景资料：在多种族动脉粥样硬化研究（梅萨）中，经验得出的饮食模式显示出与心血管疾病（CVD）风险因素的强横截面关联。目的：我们调查了5316名男性和女性的饮食模式与CVD事件风险之间的关联。设计：白色、黑人、西班牙裔和中国45-84岁的成年人，无CVD和糖尿病，在基线时完成了食物频率问卷。采用主成分分析法得出膳食模式。在中位数为4.6年的时间里，通过死亡证明和医疗记录证实了207例心血管事件的发生。（风险比五分位数5与五分位数1相比：1.82; 95% CI：在调整人口统计学和生活方式混杂因素后，全谷物和水果饮食模式与较低的CVD风险相关（0.54; 0.33，0.91）。调整腰围，血压，血脂，或inflammatorymarkers.Conclusions：从这个多民族队列的数据加强调查结果，主要是白色队列，即“健康”和“不健康”的饮食模式经验存在，这些模式是重要的生活方式预测心血管疾病发病率之间的关联和全谷物和水果的饮食模式仍然很强。美国临床营养杂志2009;90：647-54。
Background: Empirically derived dietary patterns show strong cross-sectional associations with cardiovascular disease (CVD) risk factors in the Multi-Ethnic Study of Atherosclerosis (MESA).Objective: We investigated associations between dietary patterns and risk of incident CVD in 5316 men and women.Design: White, black, Hispanic, and Chinese adults aged 45-84 y and free of CVD and diabetes completed food-frequency questionnaires at baseline. Dietary patterns were derived by using principal components analysis. Incident CVD events (n = 207) identified over a median of 4.6 y were verified by death certificates and medical records.Results: The Fats and Processed Meat dietary pattern was associated with a greater risk (hazard ratio quintile 5 compared with quintile 1: 1.82; 95% CI: 0.99, 3.35), and the Whole Grains and Fruit dietary pattern was associated with a lower risk (0.54; 0.33, 0.91) of CVD after adjustment for demographic and lifestyle confounders. Associations between CVD and the Whole Grains and Fruit dietary pattern remained strong after adjustment for waist circumference, blood pressure, lipids, or inflammatory markers.Conclusions: Data from this multiethnic cohort reinforce findings from predominantly white cohorts, ie, that "healthy" and "unhealthy" dietary patterns empirically exist and that these patterns are important lifestyle predictors of CVD incidence. Am J Clin Nutr 2009;90:647-54.