Zygotic genes that mediate torso receptor tyrosine kinase functions in the Drosophila melanogaster embryo.
Zygotic genes that mediate torso receptor tyrosine kinase functions in the Drosophila melanogaster embryo.
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介导果蝇胚胎中躯干受体酪氨酸激酶功能的合子基因。
DOI：
10.1073/pnas.88.13.5824
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发表时间：
1991
影响因子：
11.1
通讯作者：
Lipshitz,HD
中科院分区：
文献类型：
--
作者：
Strecker,TR;Yip,ML;Lipshitz,HD
决定果蝇胚胎前后末端细胞命运的发育信号是由躯干受体酪氨酸激酶传递的。本文介绍了在末端遗传层次中作用于躯干下游的合子基因座的遗传相互作用测试的结果。对 26 个具有终末发育缺陷的合子突变体的测试表明，至少有 14 个存在于这个层次结构中。与这些基因相关的表型分为三类，每一类都代表最终发育和进化的一个独特方面。其中四个基因已被分子克隆，其产物包括细胞间通讯因子和三种转录因子。
The developmental signal that specifies the fates of cells at the anterior and posterior termini of the Drosophila embryo is transmitted by the torso receptor tyrosine kinase. This paper presents the results of a genetic interaction test for zygotic loci that act downstream of torso in the terminal genetic hierarchy. Tests of 26 zygotic mutants with defects in terminal development indicate that at least 14 reside in this hierarchy. The phenotypes associated with these genes fall into three classes, each of which represents a distinct aspect of terminal development and evolution. Four of the genes have been molecularly cloned and their products include an intercellular communication factor and three kinds of transcription factors.