Reflex control of immunity.
Reflex control of immunity.
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DOI：
10.1038/nri2566
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发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Tracey KJ
中科院分区：
文献类型：
--
作者：
Tracey KJ
炎症可导致损伤甚至死亡。是什么控制着这种原始的、潜在致命的先天免疫反应？过去十年的分子和神经生理学研究揭示了一个关键的答案：免疫是由反射性运作的神经回路协调的。反射的传入弧由感觉损伤和感染的神经组成。这激活传出神经回路，包括调节免疫反应和炎性疾病进展的胆碱能抗炎通路。有可能开发出针对神经网络的治疗方法来治疗炎症性疾病。
Inflammation can cause damage and even death. What controls this primitive and potentially lethal innate immune response to injury and infection? Molecular and neurophysiological studies during the past decade have revealed a pivotal answer: immunity is coordinated by neural circuits that operate reflexively The afferent arc of the reflex consists of nerves that sense injury and infection. This activates efferent neural circuits, including the cholinergic anti-inflammatory pathway that modulate immune responses and the progression of inflammatory diseases. It might be possible to develop therapeutics that target neural networks for the treatment of inflammatory disorders.