Multiple forebrain systems converge on motor neurons innervating the thyroarytenoid muscle.
Multiple forebrain systems converge on motor neurons innervating the thyroarytenoid muscle.
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多个前脑系统汇聚在支配甲杓肌的运动神经元上。
DOI：
10.1016/j.neuroscience.2009.05.005
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发表时间：
2009
期刊：
影响因子：
3.3
通讯作者：
Cassell,MartinD
中科院分区：
文献类型：
--
作者：
VanDaele,DJ;Cassell,MartinD
本研究探讨了支配甲杓喉肌的运动神经元的中枢联系，该肌具有吞咽、呼吸和发声的功能。在完整和交感神经切除的大鼠中，将伪狂犬病病毒（PRV）接种到肌肉中。接种后3天，PRV在同侧疑核（NA）的松散分裂中的喉神经元初始感染后，扩散到同侧NA的紧凑部分，孤束核的中央和中间分裂，Botzinger复合体和小细胞网状结构4天。感染随后扩大到包括同侧颗粒和颗粒异常的顶叶岛叶皮质，杏仁核中央核的同侧内侧部，下丘脑的外侧、室旁、腹外侧和内侧视前核（通常为双侧），外侧导水管周围灰质，A7以及口侧和尾侧脑桥核。在接种后采样的最后时间点（5天），在同侧无颗粒岛叶皮质、尾顶叶岛叶皮质、前扣带皮质和对侧运动皮质中鉴定出感染的神经元。在杏仁核中，感染已经扩散到中央外侧核和基底外侧核的小细胞部分。下丘脑感染的主要特点是感染细胞的数量增加，在早期感染的地区，虽然后，背内侧，结节乳头和乳头核包含感染细胞。与以前的连接数据的比较表明PRV遵循三个相互关联的系统起源于前脑;双边系统，包括腹侧前扣带皮层，导水管周围灰质和腹侧呼吸组;同侧系统涉及顶叶岛叶皮层，中央核杏仁核和小细胞网状结构，和一个小的对侧系统起源于运动皮层。下丘脑神经支配涉及几个功能特异性核团。总的来说，这些数据意味着复杂的中枢神经系统控制的多功能甲杓肌。
The present study investigated the central connections of motor neurons innervating the thyroarytenoid laryngeal muscle that is active in swallowing, respiration and vocalization. In both intact and sympathectomized rats, the pseudorabies virus (PRV) was inoculated into the muscle. After initial infection of laryngomotor neurons in the ipsilateral loose division of the nucleus ambiguus (NA) by 3 days post-inoculation, PRV spread to the ipsilateral compact portion of the NA, the central and intermediate divisions of the nucleus tractus solitarii, the Botzinger complex, and the parvicellular reticular formation by 4 days. Infection was subsequently expanded to include the ipsilateral granular and dysgranular parietal insular cortex, the ipsilateral medial division of the central nucleus of the amygdala, the lateral, paraventricular, ventrolateral and medial preoptic nuclei of the hypothalamus (generally bilaterally), the lateral periaqueductal gray, the A7 and oral and caudal pontine nuclei. At the latest time points sampled post-inoculation (5 days), infected neurons were identified in the ipsilateral agranular insular cortex, the caudal parietal insular cortex, the anterior cingulate cortex, and the contralateral motor cortex. In the amygdala, infection had spread to the lateral central nucleus and the parvicellular portion of the basolateral nucleus. Hypothalamic infection was largely characterized by an increase in the number of infected cells in earlier infected regions though the posterior, dorsomedial, tuberomammillary and mammillary nuclei contained infected cells. Comparison with previous connectional data suggests PRV followed three interconnected systems originating in the forebrain; a bilateral system including the ventral anterior cingulate cortex, periaqueductal gray and ventral respiratory group; an ipsilateral system involving the parietal insular cortex, central nucleus of the amygdala and parvicellular reticular formation, and a minor contralateral system originating in motor cortex. Hypothalamic innervation involved several functionally specific nuclei. Overall, the data imply complex CNS control over the multi-functional thyroarytenoid muscle.