Engaging and disengaging recurrent inhibition coincides with sensing and unsensing of a sensory stimulus.
Engaging and disengaging recurrent inhibition coincides with sensing and unsensing of a sensory stimulus.
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DOI：
10.1038/ncomms15413
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发表时间：
2017-05-23
影响因子：
16.6
通讯作者：
Raman B
中科院分区：
文献类型：
--
作者：
Saha D;Sun W;Li C;Nizampatnam S;Padovano W;Chen Z;Chen A;Altan E;Lo R;Barbour DL;Raman B
Even simple sensory stimuli evoke neural responses that are dynamic and complex. Are the temporally patterned neural activities important for controlling the behavioral output? Here, we investigated this issue. Our results reveal that in the insect antennal lobe, due to circuit interactions, distinct neural ensembles are activated during and immediately following the termination of every odorant. Such non-overlapping response patterns are not observed even when the stimulus intensity or identities were changed. In addition, we find that ON and OFF ensemble neural activities differ in their ability to recruit recurrent inhibition, entrain field-potential oscillations and more importantly in their relevance to behaviour (initiate versus reset conditioned responses). Notably, we find that a strikingly similar strategy is also used for encoding sound onsets and offsets in the marmoset auditory cortex. In sum, our results suggest a general approach where recurrent inhibition is associated with stimulus ‘recognition' and ‘derecognition'. Sensory stimuli evoke temporally dynamic responses. Here the authors report that responses to odour onset and offset are orthogonally represented in the locust antennal lobe, differentially entrain oscillations, and propose a model in which they are necessary for initiation and termination of behaviour.
