Homeostasis and self-tolerance in the immune system: turning lymphocytes off.
Homeostasis and self-tolerance in the immune system: turning lymphocytes off.
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DOI：
10.1126/science.280.5361.243
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发表时间：
1998-04
期刊：
影响因子：
56.9
通讯作者：
L. Parijs;A. Abbas
中科院分区：
文献类型：
--
作者：
L. Parijs;A. Abbas
免疫系统以一种受控制的方式对微生物做出反应并清除它们，但它不会对自身抗原做出反应。一些调节机制的功能是终止对外来抗原的反应，在抗原被清除后将免疫系统恢复到基础状态，并保持对自身抗原的无反应性或耐受性。在这里，最新的进展，了解的分子基础和生理作用的机制，免疫动态平衡被审查。
The immune system responds in a regulated fashion to microbes and eliminates them, but it does not respond to self-antigens. Several regulatory mechanisms function to terminate responses to foreign antigens, returning the immune system to a basal state after the antigen has been cleared, and to maintain unresponsiveness, or tolerance, to self-antigens. Here, recent advances in understanding of the molecular bases and physiologic roles of the mechanisms of immune homeostasis are examined.