Occupational exposure to potential endocrine disruptors: further development of a job exposure matrix
Occupational exposure to potential endocrine disruptors: further development of a job exposure matrix
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DOI：
10.1136/oem.2008.042184
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发表时间：
2009-09-01
影响因子：
4.9
通讯作者：
Roeleveld, N.
中科院分区：
文献类型：
--
作者：
Brouwers, M. M.;van Tongeren, M.;Roeleveld, N.
目的：其目的是开发一个新的最新的和全面的工作接触矩阵（JEM）估计暴露于潜在的内分泌干扰物在流行病学research.Methods：化学品与内分泌干扰特性被确定从文献中，并分为10个化学品组：多环芳烃（PAH），多氯有机化合物，农药，邻苯二甲酸酯，有机溶剂，双酚A，烷基酚化合物，溴化阻燃剂、金属和其他类别。大多数化学物类可分为三至六个亚类。以1996年至2006年为重点，三位专家对353个职位接触每一化学品类别和亚组的可能性进行了评分，分为“不太可能”（0）、“可能”（1）或“可能”（2）。职称与积极的暴露概率得分提供了暴露的情况下，描述背后的scores.Results推理：暴露于任何化学组是不可能的238个职称（67%），而102（29%）的职称被归类为可能（17%）或可能（12%）暴露于一种或多种内分泌干扰物。其余13个职称提供的信息太少，无法对接触进行分类。多环芳烃、杀虫剂、邻苯二甲酸盐、有机溶剂、烷基酚化合物和金属往往与正义运动的职称有关。其余的化学团体被发现涉及很少occupations.Conclusions：尽管有一些重要的限制，这JEM可能是一个有价值的工具，暴露评估的内分泌干扰物的健康风险的研究，特别是当任务的具体信息被纳入。记录的接触情景是为了便于进一步调整正义运动，以便更广泛地使用。
Objectives: The aim was to develop a new up-to-date and comprehensive job exposure matrix (JEM) for estimating exposure to potential endocrine disruptors in epidemiological research.Methods: Chemicals with endocrine disrupting properties were identified from the literature and classified into 10 chemical groups: polycyclic aromatic hydrocarbons (PAHs), polychlorinated organic compounds, pesticides, phthalates, organic solvents, bisphenol A, alkylphenolic compounds, brominated flame retardants, metals and a miscellaneous group. Most chemical groups were divided into three to six subgroups. Focusing on the years 1996-2006, three experts scored the probability of exposure to each chemical group and subgroup for 353 job titles as "unlikely" (0), "possible" (1) or "probable" (2). Job titles with positive exposure probability scores were provided with exposure scenarios that described the reasoning behind the scores.Results: Exposure to any chemical group was unlikely for 238 job titles (67%), whereas 102 (29%) job titles were classified as possibly (17%) or probably (12%) exposed to one or several endocrine disruptors. The remaining 13 job titles provided too little information to classify exposure. PAHs, pesticides, phthalates, organic solvents, alkylphenolic compounds and metals were often linked to a job title in the JEM. The remaining chemical groups were found to involve very few occupations.Conclusions: Despite some important limitations, this JEM could be a valuable tool for exposure assessment in studies on the health risks of endocrine disruptors, especially when task specific information is incorporated. The documented exposure scenarios are meant to facilitate further adjustments to the JEM to allow more widespread use.