STUDIES IN RELATION TO BIOSYNTHESIS .7. 2-HYDROXY-6-METHYLBENZOIC ACID IN PENICILLIUM GRISEOFULVUM DIERCKX
STUDIES IN RELATION TO BIOSYNTHESIS .7. 2-HYDROXY-6-METHYLBENZOIC ACID IN PENICILLIUM GRISEOFULVUM DIERCKX
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DOI：
10.1071/ch9550539
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发表时间：
1955-01-01
影响因子：
1.1
通讯作者：
MOYE, CJ
中科院分区：
文献类型：
--
作者：
BIRCH, AJ;MASSYWESTROPP, RA;MOYE, CJ
一般的生物合成的depsides和dependrones的问题被认为是。使用羧基同位素标记的乙酸钠进行的饲养实验表明，霉菌灰黄青霉（Penicillium griseofulvum Dierckx）（Raistrick的菌株P68）通过乙酸单元的头-尾连接来合成2-羟基-6-甲基苯甲酸（VII），这与Birch和Donovan（1953）的假设雅阁。这一证明构成了对基于生化实验的假设的第一个明确支持。
The general problem of the biosynthesis of depsides and depsidones is considered. Feeding experiments using sodium acetate isotopically labelled in the carboxyl group have demonstrated that the mould Penicillium griseofulvum Dierckx (Raistrick's strain P68) elaborates 2-hydroxy-6-methylbenzoic acid (VII) by the head-to-tail linkage of acetic acid units in accord with the hypothesis of Birch and Donovan (1953). This demonstration constitutes the first definite support for the hypothesis based on bio- chemical experiments.