Binary Organic Nanoparticles with Bright Aggregation-Induced Emission for Three-Photon Brain Vascular Imaging
Binary Organic Nanoparticles with Bright Aggregation-Induced Emission for Three-Photon Brain Vascular Imaging
复制标题
用于三光子脑血管成像的具有明亮聚集诱导发射的二元有机纳米颗粒
DOI：
10.1021/acs.chemmater.0c01577
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发表时间：
2020-08-11
影响因子：
8.6
通讯作者：
Liu, Bin
中科院分区：
文献类型：
--
作者：
Liu, Maixian;Gu, Bobo;Liu, Bin
具有聚集诱导发光特性的荧光团（AIEgens）是用于细胞和血管成像的极具潜力的光学试剂。在远红光和近红外（NIR）区域具有明亮发射光的AIEgens备受青睐，但传统策略，即向AIEgens中引入给体 - 受体（D - A）结构，通常会导致荧光团的光致发光易受周围环境极性的影响。此外，由于其固有的转子结构，AIEgens通常在短波长区域有吸收，这对于成像应用来说并非最优。在本论文中，我们报道了在红色和远红区域具有可调发射光和高量子效率的二元有机纳米颗粒（NPs）。通过增加分子间距离，所获得的纳米颗粒的发光量子产率从0.01提高到0.23，并且三光子激发（3PE）截面增大，使得在1610 nm激发下，能够对8周龄的BALB/C小鼠进行高质量的、深度达1.68 mm的脑深部血管成像。
Fluorogens with aggregation-induced emission (AIEgens) are promising optical agents for cellular and vascular imaging. AIEgens with bright emission in the far-red and near-infrared (NIR) regions are highly desirable, but the traditional strategies, i.e., introducing donor-acceptor (D-A) structures into AIEgens, generally lead to fluorogens with photoluminescence that is vulnerable to the polarity of the surrounding environment. In addition, because of the intrinsic rotor structure, AIEgens usually show absorption in the short-wavelength region, which is not optimized for imaging applications. In this contribution, we report binary organic nanoparticles (NPs) with tunable emission and high quantum efficiency in the red and far-red regions. By increasing the intermolecular distance, the obtained NPs offered enhanced luminescence quantum yields from 0.01 to 0.23 and increased three-photon excitation (3PE) cross sections, enabling high-quality and deep brain vascular imaging on an 8-week-old BALB/C mouse with up to 1.68 mm upon excitation at 1610 nm.